摘要
目的 探讨不吸烟女性患肺癌的危险因素。方法 对沈阳市已确诊的 12 6例不吸烟女性原发性肺癌进行 1∶1配对的病例对照研究。调查内容包括一般状况、家族史、疾病史、居住史、被动吸烟史、职业史、饮食史、烹饪史及室内微小环境等。结果 腺癌是女性肺癌的主要组织类型 ,占 6 2 .7%。生育次数越多 ,患肺癌的危险性越高 (OR =1.46 6 ,95 %CI =1.0 6～ 2 .0 1)。肥胖指数 (BMI)越小 ,肺癌的危险性越高 (OR =2 .0 82 ,95 %CI =1.2～ 3.6 0 ) ,而且随着BMI的增加 ,肺癌的危险性降低。大量食用动物内脏 (OR =1.891,95 %CI=1.45～ 2 .46 )、玉米高粱 (OR =1.5 38,95 %CI =1.2 2～ 1.93)等能增加肺癌的危险性。使用液化石油气作燃料 (OR =1.741,95 %CI =1.2 9～ 2 .34)和室内燃煤 (OR =1.785 ,95 %CI =1.33～ 2 .38)是不吸烟女性肺癌的危险因素。一级亲属中有肺癌患者 ,不吸烟女性的肺癌危险性增高 (OR =3.18,95 %CI =2 .43～ 4.15 )。结论 低BMI、多次生育、大量食用动物内脏及玉米高粱、室内燃煤、使用液化石油气作燃料均会增加不吸烟女性患肺癌的危险性。
Objective To investigate the risk factors of lung cancer in female nonsmokers. Methods An 1∶1 matched case-control study was carried out in Shenyang, P.R.China. A questionnaire covering demographics, family history of cancer, previous disease history, living conditions, passive smoking history, occupational exposure, diet/nutritional preferences and cooking habits, sources of indoor pollution and so on was used to ask each subject. A total of 126 new cases diagnozed as primary lung cancer and 126 controls matched for age and sex were randomly selected from the female nonsmokers. Results Adenocarcinoma was the main type of female lung cancer, accounting for 62.7%. The higher number of deliveries was, the more risk of lung cancer was (OR=1.466, 95%CI=1.06-2.01). The lower the body mass index (BMI), the higher the risk of lung cancer (OR=2.082, 95%CI=1.2-3.60). With the increase of BMI, the risk of lung cancer decreased. Eating too much viscera (OR=1.891, 95%CI=1.45-2.46), maize and sorghum (OR=1.538, 95%CI= 1.22 -1.93) could increase the risk of lung cancer. Using petroleum gas as fuel (OR=1.741, 95%CI=1.29-2.34) and indoor coal burning (OR=1.785, 95%CI=1.33-2.38) were lung cancer's risk factors, too. The OR value of family cancer history of first-class relatives was 3.18 (95%CI=2.43-4.15). Conclusion The results suggest that low value of BMI, high number of child deliveries, eating too much viscera, maize and sorghum, indoor coal burning and using petroleum gas as fuel can increase the risk of lung cancer in female nonsmokers.
出处
《中国肺癌杂志》
CAS
2002年第2期98-100,共3页
Chinese Journal of Lung Cancer
基金
美国纽约中华医学基金会 (0 0 72 6)资助~~
