摘要
目的 :研究鼠妇醇提取物的镇痛作用。方法 :采用腹腔注射 (ip) 0 .6 0 %的 HAc0 .2 0 ml使小鼠产生扭体反应模型 ,观察新鲜鼠妇乙醇提取物对 HAc产生小鼠扭体反应的影响 ,小鼠扭体次数作为检测指标。结果 :相当于 2 .0 0、4 .0 0、8.0 0 g/ kg(灌胃 ,ig)和 1.2 5、2 .5 0、5 .0 0 g/ kg(皮下注射 ,sc)新鲜鼠妇乙醇提取物组小鼠腹腔注射 HAc后扭体次数比盐水对照组分别减少 2 9.6 0 %～ 36 .2 0 %和 11.0 2 %～ 36 .12 % ,并呈剂量依赖性关系。结论
Objective:To study the antalgic effects of alcohol abstracts isolated from fresh Armadillidium Vulgare in mice.Methods:The antalgic effects of alcohol abstracts isolated from fresh Armadillidium Vulgare were investigated on writhing in mice induced by intraperitoneal injection(ip)0.60%0.20ml acetic acid(HAc).The numbers of mice writhing were used as data.Results:Administration of alcohol abstracts insolated from fresh Armadillidium Vulgare could significantly reduce the numbers of writhing after ip acetic acid in mice.Compared with saline group,the mice writhing numbers reduced 29.60%～36.20% and 11.02%～36.12% at dose of 1.25,2.50,5.00g/kg(subcutaneous injection,sc)and2.00,4.00,8.00g/kg(intragastic infusion,ig),respectively correspond to fresh Armadillidium Vulgare and in dose dependent manner.Conclusion:Armadillidium Vulgare had certainly antalgic effects.
出处
《承德医学院学报》
2002年第1期10-11,共2页
Journal of Chengde Medical University
关键词
鼠妇醇提物
小鼠
镇痛作用
HAC
实验
Alcohol abstracts isolated from fresh Armadillidium Vulgare(AIAV)
Mice
Antalgic effects
Acetic acid(HAc)
