摘要
目的 观察口服米雅 BM片对头孢哌酮治疗中、重度下呼吸道感染所致的肠道菌群失调和继发真菌感染的防治作用。方法 按 APACHE 评分标准共入选 85例 (中度 4 9例 ,重度 36例 )中、重度下呼吸道细菌性感染的住院患者 ,随机分配至单纯应用头孢哌酮组和头孢哌酮加用米雅 BM片组 ;根据血液常规、生化、X线胸片、痰病原菌检查结果判定疗效 ,根据粪便常规、痰病原菌检查结果判定肠道菌群失调和继发真菌感染的情况。结果 头孢哌酮对中、重度下呼吸道细菌感染均有较为理想的疗效 ,两组临床有效率分别达 72 .0 9%和 73.81% ;单用头孢哌酮致中、重度下呼吸道感染患者肠道菌群失调的发生率、以及致重度下呼吸道感染患者继发真菌感染的发生率均显著高于头孢哌酮加用米雅 BM片组。结论 米雅
OBJECTIVE To observe the effect of control of the MIYA BM tablets on alteration of intestinal flora (AIF) and secondary mycotic infection (SMI) induced by cefoperazone, which used to treat moderate and severe infection in lower respiratory tract (LRT). METHODS The 85 inpatients (49 moderate patients and 36 severe ones) of bacterium infection in LRT are chosen by APACHE Ⅱ grade standard and divided into two groups randomly, i.e, cefoperazone (C) and cefoperazone+MIYA BM tablets (C+M) respectively. Curative effect is determined by blood routine, blood biochemistry, X ray of chest and bacteria in sputum. Generation of AIF and SMI is determined by feces routine and bacteriology in sputum. RESULTS The cefoperazone is an ideal antibiotic againt moderate and severe infection of LRT (effective rate is 72.09% and 73.81%, respectively). In C group the positive rate of AIF in moderate infection patients and positive rate of AIF and SMI in severe infection patients are higher than C+M group (P<0.05). CONCLUSIONS The MIYA BM tablets could control the AIF and SMI which are induced by broad spectrum antibiotic used to treat bacterium infection.
出处
《中华医院感染学杂志》
CAS
CSCD
2002年第4期262-264,共3页
Chinese Journal of Nosocomiology
关键词
抗生素
下呼吸道感染
肠道菌群失调
防治
头孢哌酮
Antibiotic
Lower respiratory tract infection
Prevention
Alteration of intestinal flora
