摘要
【目的】 探讨非酒精性脂肪性肝病(NAFLD)患者血清尿酸(UA)、白介素-6(IL-6)、铁蛋白(SF)水平变化及其临床意义。【方法】 选择2016年5月至2018年3月本院收治的82例NAFLD患者的临床资料,根据其病变程度将其分为轻度NAFLD组(n=27)、中度NAFLD组(n=34)、重度NAFLD组(n=21)。同时选取30例健康体检者为对照组。检测所有入选者血清中UA、IL-6、SF及血脂[总胆固醇(TC)、三酰甘油(TG)]、肝功能[天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)]、胰岛素抵抗[空腹血糖(FPG)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)]水平。【结果】 NAFLD组血清TG、AST、ALT含量均显著高于对照组(P<0.05)。中、重度NAFLD组血清FPG、FINS、UA、SF水平及HOMA-IR值均显著高于对照组和轻度NAFLD组(P<0.05),且重度NAFLD组HOMA-IR值、SF水平显著高于中度NAFLD组,差异具有统计学意义(P<0.05)。Pearson相关分析显示,NAFLD血清UA水平与BMI(r=2.572)、FINS(r=0.244)、HOMA-IR(r=2.730)均呈正相关(P<0.05),IL-6与BMI(r=2.375)、ALT(r=2.728)、HOMA-IR(r=0.254)呈正相关(P<0.05),SF与BMI(r=0.285)、ALT(r=0.372)、FINS(r=0.243)、HOMA-IR(r=0.274)呈正相关(P<0.05);IL-6与SF呈正相关(r=0.304,P<0.05)。【结论】 NAFLD患者血清UA、IL-6、SF水平均异常增高,且与病情程度相关,与胰岛素抵抗均具有高度相关性。
【Objective】 To explore serum levels of uric acid (UA), interleukin-6 (IL-6) and ferritin (SF) in patients with nonalcoholic fatty liver disease (NAFLD) and their clinical significances. 【Methods】 The clinical data of 82 patients with NAFLD admitted to our hospital from May 2016 to March 2018 were divided into the mild NAFLD group (n=27) and the moderate NAFLD group (n=34) and the severe NAFLD group (n=21). At the same time, 30 healthy subjects were selected as the control group. Serum levels of UA, IL-6, SF, blood lipids [total cholesterol (TC), triglycerides (TG)], liver function [aspartate aminotransferase (AST), alanine aminotransferase (ALT)] and insulin resistance [fasting plasma glucose (FBG), fasting Insulin (FINS), insulin resistance index (HOMA-IR)] were measured in all patients. 【Results】 Serum TG, TC,AST, ALT, UA, IL-6 levels in the NAFLD group were significant higher than those in the control group (P<0.05). Serum FBG, FINS,UA, IL-6 levels and HOMA-IR in the moderate and severe NAFLD groups were significant higher than those in the mild NAFLD group and the control group (P<0.05). The HOMA-IR value in the severe NAFLD group was significant higher than that in the moderate NAFLD group (P<0.05). Pearson correlation analysis showed that serum UA levels in cases with NAFLD were positively correlated with BMI (r=2.572), FINS (r=0.244) and HOMA-IR (r=2.730) (P<0.05) and serum IL-6 levels were positively correlated with BMI (r=2.375), ALT (r=2.728) and HOMA-IR (r=0.254) (P<0.05). It also showed that serum SF content was positively correlated with BMI (r=0.285), ALT (r=0.372), FINS (r=0.243), and HOMA-IR (r=0.274) (P<0.05). IL-6 was positively correlated with SF (r=0.304, P<0.05).【Conclusion】 Serum UA, IL-6 and SF levels in NAFLD patients were abnormally high, which were closely related to the severity of the disease and also highly correlated with insulin resistance.
作者
刘晓红
李文华
蒋淑杰
LIU Xiao-hong;LI Wen-hua;JIANG Shu-jie(the Second Hospital of Chaoyang City, Shenyang, Liaoning 122000 China)
出处
《医学临床研究》
CAS
2019年第1期55-58,共4页
Journal of Clinical Research
