摘要
针对DNA序列单碱基的不同类型突变,利用数字信号处理方法,研究了单碱基替换突变、删除突变、插入突变对DNA序列三周期功率谱的影响。研究结果表明:对于不同长度的编码序列,替换突变对序列功率谱的影响较小,删除突变和插入突变对序列功率谱的影响较大;随着序列编码区长度的减小,替换、删除、插入突变对序列编码区的功率谱影响会越来越大。对于中等长度外显子,插入突变对序列三周期功率谱影响最大,对于短外显子,删除突变对序列三周期功率谱的影响最大。研究结果可为含突变基因编码区的识别与检测提供参考。
In view of the different mutations of single-base in DNA sequence, the effects of single base substitution mutation, deletion mutation and insertion mutation on triply periodic power spectrum of DNA sequences were investigated by using digital signal processing method. The results showed that for the coding sequences with different lengths, the substitution mutation had little effect on sequence power spectrum, but the effects of deletion mutation and insertion mutation on sequence power spectrum were larger. With the decrease of the length of the sequences in coding region, substitution mutation, deletion mutation and insertion mutation had a growing impact on the power spectrum of sequences in coding region. For the medium length exons, insertion mutation had the greatest impact on triply periodic power spectrum of the sequence. For the short exons, deletion mutation had the greatest impact on triply periodic power spectrum of the sequence. The results could provide references for the identification and detection of the coding region with mutant genes.
作者
耶晓东
张军英
Ye Xiaodong;Zhang Junying(School of Physics and Telecommunication Engineering,Shaanxi University of Technology,Hanzhong,723000;School of Computer Science and Engineering,Xidian University,Xi'an,710071)
出处
《基因组学与应用生物学》
CAS
CSCD
北大核心
2019年第2期563-567,共5页
Genomics and Applied Biology
基金
基本科研业务费-自由探索类项目(JBZ170301)资助
关键词
单碱基
功率谱
外显子
突变
Single base
Power spectrum
Exon
Mutation
