摘要
心房颤动是临床常见的心律失常疾病,其发生与多种因素相关,而遗传因素是其中重要的一环。目前,通过连锁分析、全基因组关联性分析等生物信息学手段已经筛选出多个可能与房颤相关的基因,并针对这些基因的分子生物学机制开展了多项研究。本文就近年房颤的遗传及其分子机制领域取得的进展进行综述,并分析遗传因素对于房颤临床治疗的意义。
Atrial fibrillation is one of the common tachyarrhythmia and is associated with several risk factors. Genetic factor plays an important role in this disease. Several studies have identified variants by bioinformatics such as linkage analysis and genome-wide association studies. Those candidate genes are further studied for their biological mechanism. This article reviews the research progress of genomics and molecular mechanism of atrial fibrillation and provides insight into how those genetic factors improve clinical treatments.
作者
刘鼎乾
李军
过常发
王春生
LIU Ding-qian;LI Jun;GUO Chang-fa;WANG Chun-sheng(Surgery,Shanghai Institute of Cardiovascular Diseases,Zhongshan Hospital Fudan University,Shanghai 200032,China)
出处
《中国分子心脏病学杂志》
CAS
2018年第6期2700-2703,共4页
Molecular Cardiology of China
基金
国家自然科学基金(81570422
81500194)
关键词
房颤
基因
atrial fibrillation
genetics
