摘要
变应性鼻炎(allergic rhinitis,AR)是主要由Ag/IgE/FcεRI/肥大细胞(mast cell,MC)介导的Ⅰ型变态反应。其中MC脱颗粒在AR发病中居于中心地位。AR的症状在午夜或清晨加剧,其实验室参数也呈现明显的昼夜变化。最近的研究表明,昼夜节律生物钟在过敏性疾病的病理生理中起关键作用,主导了过敏反应在一天中依赖时间的变异[1-5]。
Mast cell degranulation plays a central role in the pathogenesis of allergic rhinitis.Recent studies have shown that mast cell degranulation exhibits circadian rhythm,which may be related to the periodic expression of circadian clock gene in mast cell and to the association with this kind of circadian clock genes and FcεRI.This paper focused on the biological clock mechanism of mast cell degranulation and summarized the neuroendocrine mechanism of allergic rhinitis under the regulation of biological clock.
作者
张艳廷
曹济民
赵长青
ZHANG Yanting;CAO Jimin;ZHAO Changqing
出处
《临床耳鼻咽喉头颈外科杂志》
CAS
北大核心
2019年第1期1-4,共4页
Journal of Clinical Otorhinolaryngology Head And Neck Surgery
基金
国家自然科学基金(No:81670914
No:81870707)
山西省回国留学人员重点科研资助项目(No:2014-重点3)
关键词
生物钟
鼻炎
变应性
IGE
肥大细胞
circadian clocks
rhinitis,allergic
immunoglobulin E
mast cell
