摘要
肿瘤免疫逃逸是肿瘤发生、发展的重要机制之一。垂体瘤组织局部有不同程度的固有免疫细胞和适应性免疫细胞的浸润,且与垂体瘤的侵袭性相关。研究发现,垂体瘤组织表达免疫检验点包括程序性细胞死亡蛋白-1(PD-L1)和细胞毒性T淋巴细胞相关抗原-4(CTLA-4),提示免疫检验点介导的肿瘤免疫逃逸可能在垂体瘤的发生、发展中发挥一定的作用。此外,垂体瘤患者存在白细胞介素(IL)-6、IL4等免疫调节因子的表达异常。研究肿瘤免疫在垂体瘤发病中的作用,有助于探索治疗侵袭性垂体瘤和垂体癌的新靶点。
Tumor immune evasion is one of the important pathogenesis of tumors.Pituitary tumors showed various degrees of immune cells infiltration,which were associated with the aggressive of pituitary tumors,Immunological checkpoints including programmed death-1(PD-L1)and cytotoxic T-lymphocyte-associated protein 4(CTLA-4)were detected in pituitary tumors,suggesting that tumor immune evasion mediated by immunological checkpoints may play a role in the occurrence and development of pituitary tumors.In addition,the expression of cytokines such as intedeukin(IL)-6 and IL-4 in patients with pituitary tumors were abnormal.To explore the role of tumor immunity in the pathogenesis of pituitary tumors will be contributed to searching new targets for the treatment of aggressive pituitary tumors and pituitary carcinomas.
作者
袁仙仙
朱惠娟
潘慧
Yuan Xianxian;Zhu Huijiuan;Pan Hui(Department of Endocrinology,Key Laboratory of Endocrinology of National Health Commission,The Translational Medicine Center of PUMCH,Peking Union Medical College Hospital,Chinese Academy of Medical Science and Peking Union Medical College,Beijing 100730,China)
出处
《国际内分泌代谢杂志》
2019年第1期61-64,共4页
International Journal of Endocrinology and Metabolism
关键词
垂体瘤
肿瘤免疫学
免疫检验点
Pituitary tumors
Tumor immunity
Immunological checkpoints
