摘要
目的探讨肥胖人群中血清25-羟维生素D3[25-hydroxyvitamin D3,25-(OH)D3]与其相关代谢指标的关系。方法收集2016年12月至2018年3月在江苏省人民医院减重门诊就诊的肥胖患者239例,其中男性109例,女性130例,检测其25-(OH)D3水平,分析其与肥胖、糖代谢、脂代谢指标的关系。结果所有研究人群身体质量指数(body mass index,BMI)平均为(38.57±8.10)kg/m2,25-(OH)D3水平平均为(40.53±17.05)nmol/L。男性BMI显著高于女性,差异有统计学意义(t=3.308,P=0.001)。男女之间25-(OH)D3水平无显著性差异。随BMI的增高,25-(OH)D3水平均呈下降趋势,差异有统计学意义(χ2=10.066,P<0.05)。在25-(OH)D3缺乏组中单纯性肥胖的患病率显著低于25-(OH)D3不足组,差异有统计学意义(χ2=6.121,P<0.05)。尽管25-(OH)D3缺乏组的高血压、2型糖尿病、高尿酸血症、高胰岛素血症的患病率高于25-(OH)D3不足组,但差异无统计学意义。Pearson相关性分析显示,25-(OH)D3与BMI(r=-0.197)、C-肽(C-peptide,C-P)(r=-0.134)呈负相关,与年龄呈正相关(r=0.168)。以25-(OH)D3为应变量,其他各项指标为自变量,进行多元线性回归分析,年龄、BMI、总胆固醇(total cholesterol,TC)、低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)与25-(OH)D3独立相关,β值分别为0.157、-0.164、0.513、-0.473。结论肥胖及相关代谢异常与25-(OH)D3下降密切相关,肥胖者易发生25-(OH)D3水平下降,而25-(OH)D3下降又会导致肥胖、高血压等代谢异常。
Objective To investigate the correlation between serum 25-hydroxyvitamin D3[25- hydroxyvitamin D3,25-(OH)D3] and its related metabolic indicators in obese people. Methods From December 2016 to March 2018,239 obese patients,including 109 males and 130 females,were collected from the weight reduction clinic in Jiangsu Province Hospital.Their serum 25 - (OH) D3 levels were measured,and their relationships with obesity,sugar metabolism and lipid metabolism indexes were analyzed. Result The average of body mass index (BMI) and 25 - (OH) D3 were (38.57±8.10) kg/m2 and (40.53 ±17.05)nmol/L,respectively.The BMI of men was significantly higher than that of women(t=3.308,P=0.001).There was no significant difference in the level of 25-(OH)D3 between men and women.With the increase of BMI,the level of 25-(OH) D3 showed a significantly downward trend(χ2=10.066,P<0.05).The prevalence of simple obesity in the 25 - (OH) D3 deficiency group was significantly lower than that in the 25-(OH) D3 insufficient group(χ 2=6.121,P<0.05).Compared with the insufficient group,the hypertension,type 2 diabetes,hyperuricemia and hyperinsulinemia were higher in 25-(OH) D3 deficiency group,but no significant difference has been found.Pearson correlation analysis showed that 25-(OH) D3 was negatively correlated with BMI(r=-0.197 ) and C-peptide(C-P) (r=-0.134),and it positively correlated with age(r=0.168)(P<0.05 ).Taking 25-(OH)D3 as dependent variable and other indexes as independent variables,multiple linear regression analysis was performed.Age,BMI,total cholesterol (TC),low density lipoprotein cholesterol (LDL-C) were independently correlated with 25-(OH) D3(β values were 0.157,-0.164,0.513,and-0.473 respectively). Conclusion Obesity and related metabolic abnormalities are closely related to the decline of 25-(OH) D3.The level of 25-(OH)D3 usually decreased in obese people,and the decline of 25-(OH)D3 will lead to metabolic abnormalities such as obesity and hypertension.
作者
葛秋霞
蒋理
唐未名
杨瑞霞
Ge Qiuxia;Jiang Li;Tang Weiming;Yang Ruixia(Department of Laboratory Medicine,Jiangsu Provincial People's Hospital,Nanjing 210029,China)
出处
《国际免疫学杂志》
CAS
2019年第1期32-37,共6页
International Journal of Immunology
基金
江苏省实验诊断学重点实验室项目(ZDXKB2016005).
