摘要
A novel alkaloid, chartrenoline(1), featuring an unusual 6/6/5/5-tetracyclic nucleus, was isolated from a marine Streptomyces chartreusis NA02069. The structure of 1 including its absolute configurations was established by extensive analyses of its high resolution mass, NMR and single-crystal X-ray diffraction data. A plausible biosynthetic pathway for chartrenoline(1) is proposed.
A novel alkaloid, chartrenoline(1), featuring an unusual 6/6/5/5-tetracyclic nucleus, was isolated from a marine Streptomyces chartreusis NA02069. The structure of 1 including its absolute configurations was established by extensive analyses of its high resolution mass, NMR and single-crystal X-ray diffraction data. A plausible biosynthetic pathway for chartrenoline(1) is proposed.
基金
financially supported by the National Natural Science Foundation of China(Nos.81522042,21572100,81773591,81421091,81500059,81673333,21672101,21761142001,21661140001,J1210026,and J1103512)
Natural Science Foundation of Jiangsu Province(No.BK20151397)
Fundamental Research Funds for the Central Universities(No.020814380092)
