摘要
目的探讨Silva分型在子宫颈腺癌中的应用及临床意义。方法收集2006年12月—2017年8月大连医科大学附属大连市妇产医院收治的子宫颈腺癌患者78例,患者的年龄为(45.1±9.1)岁(27~71岁);临床分期:Ⅰ期(包括Ⅰa期26例、Ⅰb期49例)75例(96%),Ⅱa期3例(4%)。收集78例患者的病理切片,根据Silva分型标准重新进行分型,分析不同Silva亚型的子宫颈腺癌患者的临床病理特征,并分析子宫颈腺癌患者的Silva分型与其临床病理特征的相关性;随访截止至2018年1月3日,随访时间为5~90个月,中位随访时间41个月,失访25例(32%,25/78),比较不同Silva亚型的子宫颈腺癌患者的预后。结果(1)78例子宫颈腺癌患者中,Silva A、B、C型分别为30、16、32例,分别占38%(30/78)、21%(16/78)、41%(32/78)。其中,30例Silva A型患者的临床分期均为Ⅰ期,包括Ⅰa期24例、Ⅰb期6例;中位肿瘤厚度(指子宫颈黏膜至肿瘤浸润最深处的距离)为2.1 mm(1.0~10.0 mm);术后检查均未见淋巴脉管间隙浸润(LVSI)、淋巴结转移及神经侵犯;24例随访患者随访期内均无瘤生存。16例Silva B型患者的临床分期均为Ⅰ期,包括Ⅰa期2例、Ⅰb期14例;中位肿瘤厚度为5.2 mm(2.0~11.0 mm);术后检查LVSI阳性4例(4/16),神经侵犯阳性1例(1/16),淋巴结转移阳性1例(1/10);13例随访患者随访期内均无瘤生存。32例Silva C型患者的临床分期为Ⅰb期29例、Ⅱa期3例;中位肿瘤厚度为11.5 mm(4.0~21.0 mm);术后检查LVSI阳性17例(53%,17/32),神经侵犯阳性5例(16%,5/32),淋巴结转移阳性8例(31%,8/26);16例随访患者随访期内复发2例(2/16),其中1例(1/16)死亡。(2)子宫颈腺癌患者的Silva分型与临床分期(r=0.754,P=0.000)、肿瘤厚度(P=0.000)、LVSI(r=0.534,P=0.000)均有显著相关性;而与淋巴结转移、神经侵犯均无显著相关性(P>0.05)。(3)Silva A、B、C型子宫内膜腺癌患者间复发率(分别为0、0、2/16)、死亡率(分别为0、0、1/16)分别比较,差异均
ObjectiveTo investigate the significance of Silva pattern system about clinical application in invasive endocervical adenocarcinoma. MethodsData obtained from the Maternity Affiliated Hospital of Dalian Medical University was analyzed, 78 endocervical adenocarcinoma cases were included from December, 2006 to August, 2017. The average age of patients was (45.1±9.1) years old (ranged 27-71 years old). Clinical stage: stageⅠa 26 cases and Ⅰb 49 cases and stage Ⅱa 3 cases. All pathological slides were reviewed, stratified cases into pattern A, B and C according to Silva system criteria. Clinicopathological parameters of three Silva subgroups were analyzed, χ2 test was used to investigate the correlation of Silva system and clinicopathological parameters. Follow-up data were collected until Jan. 3rd, 2018. The median follow-up time was 41 months (ranged 5-90 months). Kruskal-Wallis H test and Fisher test were used to analyze prognoses among different Silva subgroups.Results(1) Silva A cases accounted for 38% (30/78) of all patients, 24 cases were stageⅠa, 6 cases were stageⅠb. The median tumor thickness was 2.1 mm (ranged 1.0-10.0 mm). No lymph vascular space invasion (LVSI) and perineural invasion (PNI) was detected, and all lymph node (LN) were negative for metastatic carcinoma. All patients were alive and had no evidence of recurrence. About 21% (16/78) cases were classified as Silva B, including 2 stage Ⅰa and 14 stage Ⅰb. The median tumor thickness was 5.2 mm (ranged 2.0-11.0 mm). Several patients had LVSI (4/16), LN metastasis (1/10) or PNI (1/16), but there was no recurrence or death. Thirty two (41%, 32/78) cases were Silva C, including 29 stage Ⅰb and 3 stage Ⅱa. The median tumor thickness was 11.5 mm (ranged 4.0-21.0 mm). The incidence of LVSI (53%, 17/32), LN metastasis (31%, 8/26) or PNI (16%, 5/32) was significantly increased. There were two recurrent cases and one death cases. (2) Statistical data demonstrated that Silva pattern system was closely correlated with clinicopathological p
作者
宋光耀
王玮
王亚萍
刘明
王玉湘
刘岩
刘从容
Song Guangyao;Wang Wei;Wang Yaping;Liu Ming;Wang Yuxiang;Liu Yan;Liu Congrong(Department of Pathology,the Maternity Affiliated Hospital of Dalian Medical University,Dalian 116033, China;Department of Pathology,School of Basic Medical Sciences,Third Hospital,Peking University Health Science Center,Belling 100191,China)
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
2019年第1期13-18,共6页
Chinese Journal of Obstetrics and Gynecology
基金
大连市医学科学研究计划(1811084).
关键词
宫颈肿瘤
腺癌
淋巴转移
Silva分型
预后
Uterine cervical neoplasms
Adenocarcinoma
Lymphatic metastasis
Silva pattern system
Prognosis
