摘要
目的研究分析奥沙利铂治疗胃肠道肿瘤的不良反应及临床治疗方案。方法选取我院2016年5月-2018年4月接收的胃肠道肿瘤患者100例,平均分两组,A组第1天使用奥沙利铂治疗,第1～7天用亚叶酸钙、5-氟尿嘧啶治疗。B组化疗前进行葡萄糖酸钙静脉滴注和神经营养治疗后,第1天给予奥沙利铂、第1～7天用亚叶酸钙与5-氟尿嘧啶治疗,观察不同因素对患者发生不良反应的影响。结果对不同的原发性肿瘤类型和不同年龄患者的不良反应发生率比较无统计学意义(P> 0. 05);不同性别的神经毒性反应发生率、不同治疗方案下患者不良反应发生率比较有统计学意义(P <0. 05)。结论奥沙利铂对患有胃肠道肿瘤患者治疗的临床效果明显,值得推广。
Objective To study the adverse reactions and clinical treatment of oxaliplatin in the treatment of gastrointestinal cancer. Methods 100 cases of gastrointestinal cancer received in our hospital from May 2016 to April 2018 were divided into two groups. The A group was treated with oxaliplatin for first days and treated with leucovorin and 5-fluorouracil for first-7 days. Calcium gluconate intravenous drip and neurotrophic treatment group B before chemotherapy was given 7 days to first days after oxaliplatin,calcium folinate for first-and 5-fluorouracil treatment,to observe the effects of different factors on the incidence of adverse reaction. Results The adverse reaction of primary tumor types of patients in different age and different incidence was not statistically significant( P > 0. 05);the incidence of neurotoxicity of different sex,different treatments of patients with adverse reaction rate was statistically significant( P < 0. 05). Conclusion Oxaliplatin is effective in the treatment of patients with gastrointestinal cancer,and is worthy of promotion.
作者
刘云庚
Liu Yungeng(Department of Gastrointestinal Surgery,People's Hospital of Ganzhou,Jiangxi 341000)
出处
《辽宁医学杂志》
2018年第6期15-17,共3页
Medical Journal of Liaoning
关键词
奥沙利铂
胃肠道肿瘤
不良反应
Asha Leigh Per
Gastrointestinal neoplasms
Adverse reactions
