摘要
升麻属植物在我国分布广泛,资源丰富,环菠萝蜜烷型三萜类成分是该属植物的特征性成分。根据结构特征分为升麻醇、氢化升麻醇、shengmanol、cimiacerogenin、阿克特醇、16,23-二酮、绿升麻醇及兴安升麻醇等类型。现代药理研究表明其具有细胞毒、抗骨质疏松、抗病毒、抗炎、抑制核苷转运、神经保护、抗氧化及抑菌等多种药理作用。该文对升麻属植物的资源分布、环菠萝蜜烷型三萜类化合物的骨架结构及生物活性进行了归纳,以期为该类化合物的研究开发利用提供参考。
The genus Actaea plants are widely distributed in China,and the cycloartane triterpenoids are the characteristic constituents of this genus. They are divided into types of cimigenol,hydroshengmanol,shengmanol,cimiacerogenin,acteol,16,23-diketo,foetidonol,dahurinol,etc. Cycloartane triterpenoids show many biological activities,such as cytotoxicity,anti-osteoporosis,antiviral,anti-inflammatory,anti-nucleoside transport,neuroprotective,anti-oxidant,antibacterial activities. The present paper reviewed the distribution of the plant resources of Actaea,chemical structures and biological activities of cycloartane triterpenoids,aiming to provide a reference for the further research in the future.
作者
夏红旻
戴衍朋
孙立立
XIA Hong-min;DAI Yan-peng;SUN Li-li(Taishan Scholar-Distinguished Experts Position,Key Disciplines on Analysis of Traditional Chinese Medicine, the Key Unit for Research of Technique and Principle of Honey-processing and Carbonizing of SATCM,Shandong Key Laboratory of Chinese Medicine Quality Standard Research,Shandong Academy of Chinese Medicine,Ji'nan 250014,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2018年第20期4000-4010,共11页
China Journal of Chinese Materia Medica
基金
山东省中医药科技发展计划项目(2011-180)
关键词
升麻属
环菠萝蜜烷型三萜
化学结构
生物活性
Actaea
cycloartane triterpenoids
chemical structure
biological activities
