摘要
获得性免疫缺陷综合征(acquired immunodeficiency syndrome,AIDS)是由人类免疫缺陷病毒(human immunodeficiency virus,HIV)感染所引起的一种严重危胁人类健康的传染性疾病。高效抗逆转录病毒治疗(highly active antiretroviral therapy,HAART)的有效实施,使病毒复制减少,母婴传播风险降低,HIV感染者生活质量明显改善,预期寿命得以延长。因此,越来越多HIV感染者将生育计划纳入考虑范畴。辅助生殖技术(assisted reproductive technology,ART)及合理的分娩方式可有效降低伴侣及子代传播风险,同时增加受孕率,使得HIV感染者对ART的需求上升。本文从HIV感染及抗病毒治疗对生育力的影响、HIV感染者ART助孕策略、预防HIV母婴传播的产科管理和抗病毒措施、ART治疗伦理及实验室管理等方面进行阐述。
Acquired immunodeficiency syndrome (AIDS) is a severe infectious disease caused by human immunodeficiency virus (HIV) infection, which is a serious threat to human health. The effective implementation of highly active antiretroviral therapy (HAART) has reduced virus replication, decreased the risk of mother-to-child transmission, significantly improved the quality of life of HIV-infected individuals and extended their life expectancy. Therefore, more and more HIV-infected people take fertility into account. As to partners and offspring, assisted reproductive technology (ART) and reasonable delivery methods can effectively reduce the risk of transmission and improve the rate of conception, so there is an increasing demand for ART among HIV-infected individuals. The purpose of this article is to summarize the research progress in impact of HIV infection and antiviral treatment on fertility, ART assisted pregnancy strategies for HIV-infected patients, obstetric management and anti-viral measures to prevent mother-to-child transmission of HIV, laboratory management and related ethical problems.
作者
欧阳璐
王恩银
孙莹璞
Ouyang Lu;Wang Enyin;Sun Yingpu(The Reproductive Medicine of Center of the First Affiliated Hospital of Zhengzhou University,Henan Key Laboratory of Reproduction and Genetics,Zhengzhou 450052,China)
出处
《中华生殖与避孕杂志》
CAS
CSCD
北大核心
2018年第12期1023-1027,共5页
Chinese Journal of Reproduction and Contraception
