摘要
目的研制一种兼具长效和防水功能的驱蚊产品。方法以性状、稳定性、防水性能、缓释性能为评价指标,对鲸蜡基磷酸酯2800B、黄原胶、聚维酮K30、避蚊胺用量进行单因素考察;以完全有效驱避时间为评价指标,对驱蚊效能评价。结果鲸蜡基磷酸酯2800B、黄原胶、聚维酮K30、避蚊胺的最佳用量分别为2%、0.6%、2%和15%;15%和35%避蚊胺长效防水驱蚊乳的完全有效驱避时间分别为(11.16±0.29)h、(12.33±0.29)h,高于相同药物浓度的长效驱蚊霜和3M ULTRATHONTM驱蚊乳膏。结论本方法制备的避蚊胺长效防水驱蚊乳能有效满足军民对长时间驱蚊和防水的需求。
Objective To preparea a long-acting and water-repellent anophelifuge product.Methods Single-factor studies were conducted on the dosage of cetyl phosphate 2800 B,xanthan gum,plasdone K30 and deet,with appearance,stability,waterproofness and sustained release performance as the evaluation indices.The mosquito repellency of the prepared anophelifuge product was evaluated with the mosquitorepelling time as the evaluation index.Results The optimum dosage of cetyl phosphate 2800 B,xanthan gum,plasdone K30 and deet was 2%,0.6%,2%,and 15%respectively.The mosquito-repelling time of this anophelifuge product with 15%and 35% deet was(11.16±0.29)h and(12.33±0.29)h respectively,which was longer than that of another anophelifuge product at the same deet concentration used in the Chinese and American army.Conclusion The anophelifuge product prepared in this study can meet the needs of soldiers and civilians for long-acting and water-repellent anophelifuge products.
作者
曾令军
陶春
王佳琳
张倩
宋洪涛
ZENG Ling-jun;TAO Chun;WANG Jia-lin;ZHANG Qian;SONG Hong-tao(Department of Pharmacy,Fuzhou General Hospital of Nanjing Military Region,Fuzhou 350025,China;College of Pharmacy,Fujian Medical University,Fuzhou 350108,China)
出处
《解放军药学学报》
CAS
CSCD
2018年第6期533-535,570,共4页
Pharmaceutical Journal of Chinese People's Liberation Army
基金
福州总医院军民融合研究专项课题
No.2017J04
关键词
避蚊胺
乳剂
长效
防水
deet
emulsion
long-acting
water-repellent
