摘要
目的探讨夏氏睡眠1号治疗虚证型抑郁性睡眠障碍的临床效果及对患者5-羟色胺(5-HT)、去甲肾上腺素(NE)水平的影响。方法将丽水市第二人民医院2016年12月—2017年12月收治的120例经中医辨证为虚证型抑郁性睡眠障碍患者采用随机数字法分为2组,每组60例。对照组给予盐酸氟西汀胶囊治疗,观察组在对照组的基础上加用夏氏睡眠1号治疗。治疗后,比较2组患者汉密尔顿抑郁量表(HAMD)评分、阿森斯失眠量表(AIS)评分、血清5-HT、血清NE水平的变化及不良反应(头晕头痛、恶心、食欲减退、口干、便秘、失眠)发生情况与临床疗效。结果观察组总有效率(88. 33%)大于对照组(68. 33%,P <0. 05)。治疗后,2组HAMD、AIS评分均明显降低(均P <0. 05),且观察组显著低于对照组(均P <0. 05)。治疗后,2组血清5-HT、NE水平均显著升高(均P <0. 05),且观察组明显高于对照组(均P <0. 05)。观察组不良反应发生率为18. 33%,对照组不良反应发生率为41. 67%,差异有统计学意义(P <0. 05)。结论夏氏睡眠1号治疗虚证型抑郁性睡眠障碍临床疗效显著,可有效缓解患者失眠症状,不良反应少,其作用机制可能与夏氏睡眠1号能够上调患者血清5-HT及NE水平有关。
Objective To investigate the clinical effect of Xiashi Shuimian Yihao on depressive sleep disorder with deficiency syndrome and its effect on serotonin( 5-HT) and norepinephrine( NE). Methods A total of 120 patients with depressive sleep disorder diagnosed as deficient syndrome of TCM in our hospital from December 2016 to December 2017 were divided into two groups by random number method,with 60 cases in each group. The control group was treated with fluoxetine hydrochloride capsules,and the observation group was treated with Xiashi Shuimian Yihao based on the control group. After treatment,Hamilton Depression Scale( HAMD) score,Ascension Insomnia Scale( AIS) score,serum5-HT,serum NE level,adverse reactions( dizziness headache,nausea,loss of appetite,dry mouth),and effect of two groups were compared. Results Total effective rate of observation group( 88. 33%) was significantly higher than that of the control group( 68. 33%,P < 0. 05). After treatment,the HAMD and AIS scores of the two groups were significantly lower( all P < 0. 05),the HAMD and AIS scores of observation group was lower than control group( all P < 0. 05). After treatment,serum 5-HT and NE levels were significantly increased in the two groups( all P < 0. 05),and serum 5-HT and NE levels of observation group was significantly higher than the control group( all P < 0. 05). The adverse incidence of observation group( 18. 33%) was significantly lower than control group( 41. 67%,P < 0. 05). Conclusion Xiashi Shuimian Yihao could effectively treat depressive sleep disorder with deficiency syndrome,alleviate the symptoms of insomnia and reduce the adverse reactions. The mechanism may be related to its upregulation of serum serotonin and norepinephrine.
作者
朱桂东
王莹
吴雷
徐伟杰
曹江
夏朝云
ZHU Gui-dong;WANG YingF;WU Lei(Department of Integrated Traditional Chinese and Western Medicine,Lishui Second People's Hospital,Lishui,Zhejiang 323000,China)
出处
《中华全科医学》
2019年第1期111-113,共3页
Chinese Journal of General Practice
基金
浙江省中医药科技计划项目(2013ZB149)
