摘要
目的探讨Pygopus2(PYGO2)基因在乳腺癌组织中的表达及临床意义。方法收集Oncomine数据库中关于PYGO2的信息,利用Kaplan-Meier Plotter数据库分析PYGO2与乳腺癌患者预后的关系。结果 Oncomine数据库中共收集了45项研究(包括3 730个样本)涉及PYGO2在乳腺癌组织和正常组织中表达的比较。与正常组织相比,PYGO2在乳腺癌组织中高表达(P<0.05)。PYGO2高表达组乳腺癌患者的总体生存率(HR=0.69,95%CI:0.51～0.95,P=0.021)、无复发生存率(HR=0.60,95%CI:0.51～0.70,P<0.001)以及无远处转移生存率(HR=0.61,95%CI:0.43～0.87,P=0.005)均优于低表达组。结论 PYGO2在乳腺癌组织中高表达,且与乳腺癌患者不良预后有关,可能是评估乳腺癌患者预后的潜在生物标志物。
Objective To explore the expression of Pygopus2(PYGO2)and its clinical significance in breast cancer. Methods PYGO2 data were retrieved from the Oncomine database and the relationship between PYGO2 and prognosis of breast cancer patients was retrieved from an online survival analysis tool"Kaplan-Meier Plotter"database. Results A total of 45 studies(including 3,730samples) were involved PYGO2 in breast cancer tissues and normal tissues. PYGO2 expression levels in breast cancer was higher than that in normal tissues(P<0.05). Kaplan-Meier Plotter of survival analysis indicated that high expression of PYGO2 was closely associated with better survival in breast cancer,including overall survival(HR=0.69,95%CI: 0.51-0.95,P=0.021),relapse-free survival(HR=0.60,95%CI: 0.51-0.70,P<0.001)and distant metastasis-free survival(HR=0.61,95%CI: 0.43-0.87,P=0.005). Conclusion PYGO2 is highly expressed in breast cancer tissues and associated with poor prognosis in breast cancer patients,which may be a potential biomarker for estimating the prognosis of breast cancer.
作者
李开国
王茹月
杨晓慧
曲颂
Li Kaiguo;Wang Ruyue;Yang Xiaohui;Qu Song(Department of Radiation Oncology,Affiliated Tumor Hospital of Guangxi Medical University,Cancer Institute of Guangxi Zhuang Autonomous Region,Key Laboratory of Education Ministry for Early Prevention and Treatment of Cancer in Guangxi Zhuang Autonomous Region;Emergency Department,the Second Affiliated Hospital of Guangxi Medical University,Nanning 530021,China)
出处
《中国癌症防治杂志》
CAS
2018年第6期449-453,共5页
CHINESE JOURNAL OF ONCOLOGY PREVENTION AND TREATMENT
基金
广西高校中青年教师基础能力提升资助项目(KY2016YB083)
