摘要
目的:分析微小核糖核酸-211(micro ribonucleic acid-211,miR-211)、La相关蛋白1(La-associated protein 1,LARP1)、转录辅助因子退变样蛋白4(transcription-assisted factor deformable protein 4,VGLL4)在胃癌组织中的表达及意义。方法:收集98例胃癌患者,并取胃癌组织距离肿瘤边缘5 cm的癌旁组织43例。比较胃癌组织和癌旁组织miR-211,LARP1,VGLL4表达情况和以上指标与胃癌患者临床病理特征及生存情况的关系。结果:胃癌患者miR-211及LARP1高表达率高于癌旁组织,VGLL4高表达率低于癌旁组织(均P<0.05)。MiR-211,LARP1,VGLL4表达在TNM分期、淋巴结转移、浸润深度中差异有统计学意义(P<0.05)。MiR-211及LARP1高表达者3年生存率分别低于miR-211及LARP1低表达者,VGLL4高表达者3年生存率高于低表达者(P<0.05)。Cox比例风险模型分析显示TNM分期、淋巴结转移、浸润深度、miR-211、LARP1为胃癌预后的危险因素,VGLL4为保护因素。miR-211与LARP1呈正相关,miR-211与VGLL4,LARP1与VEGLL4呈负相关。结论:MiR-211及LARP1在胃癌组织中呈高表达,VGLL4呈低表达,和胃癌生物学行为相关,可能成为胃癌诊治的潜在生物学指标。
Objective: To analyze the expression and significance of micro ribonucleic acid-211(miR-211), La-associated protein 1(LARP1) and transcription-assisted factor deformable protein 4(VGLL4) in gastric cancer tissues. Methods: We collected 98 patients with gastric cancer, and 43 patients with gastric cancer whose tissues were 5 cm from the edge of tumor were selected. Expression of miR-211, LARP1 and VGLL4 between gastric cancer tissues and adjacent tissues were compared, and the relationship between the clinicopathological features and survival of patients with gastric cancer and the relationship with above indicators. Results: High expression rates of miR-211 and LARP1 in gastric cancer patients were higher than that in adjacent tissues, and the high expression rates of VGLL4 were lower than that in adjacent tissues(both P<0.05). The expressions of miR-211, LARP1 and VGLL4 were statistically different in TNM stage, lymph node metastasis and infiltration depth(P<0.05). Three-year survival rates of high expression in miR-211 and LARP1 were lower than those of low expression of miR-211 and LARP1, and 3-year survival rates of high expression of VGLL4 were higher than those of low expression(P<0.05). Cox proportional risk model analysis showed that TNM staging, lymph node metastasis, infiltration depth, miR-211 and LARP1 were risk factors for gastric cancer prognosis, and VGLL4 was a protective factor. MiR-211 and LARP1 were positively correlated, while miR-211 and VGLL4, LARP1 and VEGLL4 were negatively correlated. Conclusion: MiR-211 and LARP1 are highly expressed in gastric cancer tissues, and VGLL4 is low expression, related to the biological behavior of gastric cancer. It may be a potential biological indicator for diagnosis and treatment of gastric cancer.
作者
段军
邓少华
邓涛
罗娟
谢武飞
DUAN Jun;DENG Shaohua;DENG Tao;LUO Juan;XIE Wufei(Department of Surgery,Yongchuan Chinese Medicine Hospital, Chongqing Medical University,Chongqing 402160,China)
出处
《临床与病理杂志》
2018年第11期2343-2350,共8页
Journal of Clinical and Pathological Research
