摘要
额外的脂肪累积可诱发机体代谢紊乱以及心血管疾病的发生,主要表现为免疫细胞的浸润、抗炎和促炎症因子分泌的改变,而上述机制的变化又可使机体呈现全身性、低度炎症反应。代谢手术可明显改善肥胖患者机体炎症因子的合成、分泌。本文将阐述代谢手术引起的体重下降对于脂肪组织内和循环中炎症因子水平的影响。
Excess fat mass accumulation can lead to a wide range of metabolic and cardiovascular complications. It includes immune cell infiltration and altered secretion of anti-and proinflammatory mediators,which contribute to systemic,low-grade inflammation.Bariatric surgery may reverse the altered secretory profile observed in the adipose tissue of severe obesity patients.This article will review available literature documenting the impact of surgeryinduced weight loss on tissue expression or circulating levels of a broad spectrum of inflammatory mediators.
作者
张若蹊
刘殿刚
Zhang Ruoxi;Liu Diangang(Department of General Surgery,Xuanwu Hospital,Capital Medical University,Beijing 100053,China)
出处
《国际外科学杂志》
2018年第12期858-864,共7页
International Journal of Surgery
基金
北京市卫生系统高层次卫生技术人才培养项目(2015-3-066).
关键词
肥胖症
脂肪组织
系统性炎症反应综合征
抗炎因子
促炎因子
代谢手术
Obesity
Adipose tissue
Systemic inflammatory response syndrome
Anti-inflammatory factor
Pro-inflammatory factor
Bariatric surgery
