摘要
目的:观察宣痹消痛方用于类风湿性关节炎(RA)抗炎的临床价值。方法:将我院86例RA患者按随机数表法均分为观察组(宣痹消痛方辅助常规西药治疗)与对照组(常规西药治疗)。比较两组临床疗效、中医症状积分、炎症因子水平[白细胞介素-1β(IL-1β)、肿瘤坏死因子(TNF-α)、前列腺素E2(PGE2)、血管内皮生长因子(VEGF)]、不良反应发生率。结果:观察组总有效率高于对照组(P<0. 05)。两组治疗后关节疼痛、发热、关节活动障碍、晨僵、口渴症状积分较治疗前降低,且观察组低于对照组(P<0. 05)。两组治疗后IL-1β、TNF-α、PGE2、VEGF水平均较治疗前降低,且观察组低于对照组(P<0. 05)。两组不良反应发生率比较无显著差异(P> 0. 05)。结论:宣痹消痛方辅助常规西药治疗RA疗效显著,可改善患者临床症状,降低炎症因子水平,且不良反应并未显著增加,临床应用价值较高。
Objective:To investigate the clinical value of using Xuanbi Xiaotong Recipe in the treatment of rheumatoid arthritis (RA).Methods :86cases of RA patients in our hospital were randomly divided into observation group (Xuanbi Xiaotong Recipe combined with conventional western medicine)and controlled group (conventional western medicine).The clinical effica- cy,TCM symptom scores,inflammatory factors [interleukin-1beta (IL-1beta),tumor necrosis factor (TNF-α),prostaglandin E2 (PGE2),vascular endothelial growth factor (VEGF)]and adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was higher than that of the controlled group (P<0.05).The main clinical symptom scores of the two groups were lower than those before the treatment,and the observation group was lower than that of the controlled group (P<0.05).After treatment,the levels of IL-1,TNF-α,PGE2 and VEGF in the two groups were lower than those before the treatment,and the observation group was lower than that of the controlled group (P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).Conclusion:Using Xuanbi Xiaotong Recipe combined with routine western Medicine in treating RA has remarkable curative effect,can improve the clinical symptoms and reduce the level of inflammatory factors.The adverse reactions have not increased significantly.The clinical application value is higher.
作者
刘建梅
刘亚梅
刘宇
LIU Jianmei;LIU Yamei;LIU yu(Baota District Nanniwan Central Health Hospital of Yan'an City (Yan'an Shaanxi 716000,China);Yan'an People's Hospital (Yan'an Shaanxi 716000,China);Liulin Community Health Service Center of Qilipunof Yan'an City (Yan'an Shaanxi 716000,China))
出处
《四川中医》
2019年第1期146-149,共4页
Journal of Sichuan of Traditional Chinese Medicine
