摘要
目的检测LINC00161在鼻咽癌组织中表达情况并探讨其与患者临床病理参数和预后之间的关系。方法 2012年3月～2014年3月在郑州大学附属郑州中心医院诊治的鼻咽癌患者46例为研究对象,选取同期鼻咽炎患者40例作为对照组。采用实时荧光定量PCR(qRT-PCR)技术检测病理组织中LINC00161表达情况,分析LINC00161表达对鼻咽癌患者临床病理参数及3年总生存率的影响。结果与对照组比较,LINC00161在鼻咽癌组织中相对表达量明显增高,差异有统计学意义(P <0.05)。LINC00161表达与患者T分期、N分期、临床分期和病理分化程度等有关,差异有统计学意义(P <0. 05)。KaplanMeier生存曲线分析表明,LINC00161高表达者3年总生存率低于LINC00161低表达者(38.71%vs 86.67%,P<0.05);晚期NPC患者中LINC00161高表达者3年总生存率低于LINC00161低表达者3年总生存率(35.74%vs 77.78%,P<0.05)。COX分析结果表明,LINC00161、TNM分期是影响鼻咽癌患者预后的独立危险因素(HR=2. 348,95%CI:1. 128～4. 888, P <0. 05; HR=2. 183,95%CI:1.097～4.344,P<0.05)。结论 LINC00161在鼻咽癌组织中高表达,与患者T分期、N分期、临床分期、病理分化和3年总生存率有关,是影响鼻咽癌患者预后的独立危险因素。
Objective To detect the expression of LINC00161 in nasopharyngeal carcinoma tissues and to explore its relationship with the clinicopathological parameters and prognosis of the patients. Methods Forty-six cases of nasopharyngeal carcinoma patients who treated in our hospital from March 2012 to March 2014, and forty cases of nasopharyngitis patients were selected as control group. Real time fluorescence quantitative PCR(qRT-PCR) technology was used to detect the expression of LINC00161 in pathological tissues,the effect of LINC00161 expression on clinicopathological parameters and 3 year overall survival rate of nasopharyngeal carcinoma patients was analyzed. Results Compared with the control group, the relative expression of LINC00161 in nasopharyngeal carcinoma tissues was significantly increased, and the difference was statistically significant( P <0. 05). The expression of LINC00161 was related to T staging,N staging, clinical staging and pathological differentiation degree, and the difference was statistically significant(P < 0.05). The Kaplan-Meier survival curve analysis showed that the 3 year overall survival rate of the LINC00161 high expression patients was lower than that of LINC00161 low expression patients(38. 71% vs 86. 67%, P <0. 05). The 3 year overall survival rate of the LINC00161 high expression was lower than that of the LINC00161 low expression in the advanced NPC patients(35.74% vs 77. 78%, P <0. 05). COX analysis results showed that LINC00161 and TNM staging were independent risk factors for the prognosis of patients with nasopharyngeal carcinoma(HR =2,348, 95% CI: 1.128-4.888, P<0.05, HR =2.183, 95% CI: 1.097-4.344, P<0.05). Conclusion LINC00161 is highly expressed in nasopharyngeal carcinoma tissues. It is associated with T staging, N staging, clinical staging, pathological differentiation and 3 year overall survival rate. It is an independent risk factor for prognosis of nasopharyngeal carcinoma.
作者
韩涛
于敏
李玉杰
Han Tao;Yu Min;Li Yujie(Zhengzhou Center for Disease Control and Prevention,Henan 450000,China)
出处
《医学研究杂志》
2018年第12期177-181,共5页
Journal of Medical Research
关键词
鼻咽癌
LINC00161
表达
临床病理特征
生存率
Nasopharyngeal carcinoma
LINC00161
Expression
Clinicopathological features
Survival rate
