摘要
目的研究红金消结胶囊联合注射用醋酸曲普瑞林治疗子宫肌瘤的临床疗效。方法选取2017年6月—2018年6月十堰市中西医结合医院收治的120例子宫肌瘤患者作为研究对象,将患者随机分为对照组和治疗组,每组各60例。对照组患者肌肉注射注射用醋酸曲普瑞林,3.75 mg/次,1次/d;治疗组在对照组的基础上口服红金消结胶囊,1.2 g/次,3次/d,经期停用。两组患者均连续治疗3个月。观察两组患者的临床疗效,同时比较治疗前后两组的子宫和子宫肌瘤体积、性激素水平。结果治疗后,治疗组和对照组的总有效率分别为73.3%、90.0%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者子宫体积和子宫肌瘤体积均明显减小,同组治疗前后比较差异具有统计学意义(P<0.05);治疗后,治疗组患者的子宫体积和子宫肌瘤体积显著低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者的促卵泡素(FSH)、促黄体生成素(LH)、雌二醇(E2)水平均明显降低,同组治疗前后比较差异具有统计学意义(P<0.05);治疗后,治疗组患者血清性激素水平显著低于对照组,两组比较差异具有统计学意义(P<0.05)。结论红金消结胶囊联合注射用醋酸曲普瑞林治疗子宫肌瘤具有较好的临床疗效,能够显著减小患者子宫和子宫肌瘤体积,改善患者性激素水平,安全性较高,具有一定的临床推广应用价值。
Objective To investigate the clinical efficacy of Hongjin Xiaojie Capsules combined with Triptorelin Acetate for injection in treatment of uterine fibroids. Methods Patients(120 cases) with uterine fibroids in Shiyan Hospital of Integrated Traditional and Western Medicine from June 2017 to June 2018 were randomly divided into control and treatment groups, and each group had 60 cases. Patients in the control group were im administered with Triptorelin Acetate for injection, 3.75 mg/time, once daily. Patients in the treatment group were po administered with Hongjin Xiaojie Capsules on the basis of the control group, 1.2 g/time, three times daily, and was discontinued during menstrual period. Patients in two groups were treated for 3 months. After treatment, the clinical efficacy was evaluated, the uterine and uterine fibroids volumes and the sex hormone levels in two groups were compared. ResultsAfter treatment, the clinical efficacy in the control and treatment groups were 73.3% and 90.0%, and there were differences between two groups(P < 0.05). After treatment, the uterine and uterine fibroids volume in two groups was significantly decreased, and the difference was statistically significant in the same group(P < 0.05). After treatment, the uterine and uterine fibroids volumes in the treatment group were significantly lower than those in the control group, with significant difference between two groups(P < 0.05). After treatment, the levels of FSH, LH and E2 in two groups were significantly decreased, and the difference was statistically significant in the same group(P < 0.05). After treatment, the sex hormone levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups(P < 0.05). Conclusion Hongjin Xiaojie Capsules combined with Triptorelin Acetate for injection has clinical curative effect in treatment of uterine fibroids, can effectively reduce the uterine and uterine fibroids volume, and improve the sex hormones levels, with good safety,
作者
许立敏
郑春艳
XU Li-min;ZHENG Chun-yan(Department of Obstetrics,Shiyan Hospital of Integrated Traditional and Western Medicine,Shiyan 442011,China;Department of Obstetrics,4th (Xing Yuan)Hospital of Yulin,Yulin 719000,China)
出处
《现代药物与临床》
CAS
2018年第12期3289-3292,共4页
Drugs & Clinic
关键词
红金消结胶囊
注射用醋酸曲普瑞林
子宫肌瘤
子宫肌瘤体积
性激素
Hongjin Xiaojie Capsules
Triptorelin Acetate for injection
uterine fibroids
uterine fibroids volume
sex hormone
