摘要
目的观察金凤丸与激素人工周期干预宫腔粘连(IUA)分离术后的临床疗效。方法选取253例IUA患者的临床资料进行随机对照研究,采用随机数字法分为3组,激素人工周期组(n=83)、金凤丸组(n=86)和联合治疗组(n=84),3组均连续治疗2个月经周期,检测治疗前、后患者的月经情况、宫腔恢复情况及子宫动脉血流动力学指标。结果激素人工周期组治疗后宫腔再粘连为24例,总有效率为71.1%(59/83),金凤丸组治疗后宫腔再粘连为11例,总有效率为87.2%(75/86),联合治疗组治疗后宫腔再粘连为3例,总有效率为96.4%(81/84),三组间两两比较差异均有统计学意义(激素人工周期组和金凤丸组P=0.036 8,激素人工周期组和联合治疗组P=0.016 1,金凤丸组和联合治疗组P=0.044 9)。与激素人工周期组比较,金凤丸组、联合治疗两组子宫动脉血流动力学指标显著改善(激素人工周期组和金凤丸组P=0.016 4,激素人工周期组和联合治疗组P=0.009 3)。结论金凤丸在IUA分离术后使用,可改善子宫内膜修复,预防再次粘连的发生,同时与激素人工周期治疗方案具有协同作用,值得临床推广。
Objective To observe the clinical efficacy of Jinfeng pill and post hormone artificial cycle interferes transcervical resection of adhesion.Methods A total of 253 clinical intrauterine adhesions (IUA) patients were selected and analyzed. By using the random number method, they were divided into 3 groups, hormonal artificial cycle group (n=83), Jinfeng pill group (n=86) and combined treatment group (n=84). Situations of menstruation period, uterine cavity recovery and uterine arteries haemodynamic index were compared before and after treatment for 2 continuous menstrual cycle.Results In hormonal artificial cycle group, group B, and group C, there were 24 cases, 11 cases, and 3 cases of IUA again after treatment respectively, the total effective rate was 71.1% (59/83), 87.2% (75/86), and 96.4% (81/84). Pairwise comparisons between the three groups were statistically significant (P=0.036 8 between hormonal artificial cycle group and Jinfeng pill group, P=0.016 1 between hormonal artificial cycle group and combined treatment group, P=0.044 9 between Jinfeng pill group and combined treatment group). Compared with hormonal artificial cycle group, uterine arterial flow mechanical indexes in Jinfeng pill group and combined treatment group were significantly improved (P=0.016 4 between hormonal artificial cycle group and Jinfeng pill group, P=0.009 3 between hormonal artificial cycle group and combined treatment group).Conclusion Jinfeng pill is an effective proposal for improving endometrial repairing and preventing intrauterine re-adhesion, whilst having synergistic effect with hormone artificial cycle proposal which is worth to popularizing in clinic.
作者
黄东红
苏思思
殷明红
Huang Donghong;Su Sisi;Yin Minghong(Nanan Hospital of Fujian Province,Nanan 362300,China;Shanghai First Maternity and Infant Hospital,Shanghai 200040,China)
出处
《中华生殖与避孕杂志》
CAS
CSCD
北大核心
2018年第11期931-934,共4页
Chinese Journal of Reproduction and Contraception
关键词
金凤丸
宫腔粘连分离术
激素人工周期
子宫动脉血流动力学指标
Jinfeng pill
Transcervical resection of adhesion
Hormone artificial cycle
Uterine arteries haemodynamic index
