摘要
流行性感冒病毒简称流感病毒,可以引起禽、猪(Sus)等多种动物以及人的感染和发病,是重要的人畜共患病病原.近年来,多种新型禽流感病毒的出现及其在世界范围内的流行,导致人感染禽流感病例增加,加剧了禽流感病毒的公共卫生学危害.流感病毒感染宿主后,除主要引起呼吸系统疾病外,也可以导致中枢神经系统等相关病症,与疾病的预后密切相关.本文综述了人流感病毒和禽流感病毒神经嗜性的相关研究进展,从流感病毒相关性脑病的临床特点、流感病毒入侵中枢神经系统的途径,以及发生神经嗜性的分子机制等几个方面来阐述流感病毒引发神经嗜性的过程与机制,以期加深对人和禽流感病毒神经嗜性的认识和理解.
Influenza A virus is a crucial zoonotic pathogen that is prevalent in diverse avian and mammalian species.With the widespread emergence of novel avian influenza viruses (AIVs),diseases in humans caused by these viruses have increased.Thus,AIVs have become a critical concern to public health.Apart from respiratory symptoms,neurological symptoms can also be caused by AIV infections.The neurotropism of AIV can cause serious illnesses;therefore,it is considered a key criterion in the prognosis of the disease.To summarize the neurotropism of influenza viruses,we review the related findings on neurotropism of human influenza virus and AIV in the following three aspects:the clinical features of influenza virus-associated encephalopathy,the mechanism by which influenza virus invades the central nervous system,and the molecular mechanism of neurotropism.
作者
蒋智民
张谞霄
魏凡华
刘金华
蒲娟
JIANG ZhiMin;ZHANG XuXiao;WEI FanHua;LIU JinHua;PU Juan(College of Veterinary Medicine,China Agricultural University,Beijing 100094,China;College of Agriculture,Ningxia University,Yinchuan 750021,China)
出处
《中国科学：生命科学》
CSCD
北大核心
2018年第12期1252-1262,共11页
Scientia Sinica(Vitae)
基金
国家重点研发计划(批准号:2016YFD0500204)资助
关键词
流感病毒
神经嗜性
人
禽
influenza A virus
neurotropism
human
avian
