摘要
血脑屏障(BBB)限制了绝大多数药物进入脑部,从而成为中枢神经系统疾病治疗的主要障碍。基于仿生策略的脑部疾病靶向递药系统,是近年来极受研究者关注的具有广阔应用前景的药物递送系统。在脑部肿瘤病理环境中,BBB的血管上皮组织或肿瘤细胞高表达营养转运体及特定信号受体,以支撑肿瘤快速增殖的需要。综述近年来基于营养物质转运体及信号受体途径介导的脑部肿瘤仿生靶向递药研究进展。
The blood-brain barrier (BBB) restricts the entry of most drugs into the brain, making it a major therapeutic obstacle to the central nervous system diseases. The brain-targeting biomimetic drug delivery strategies have recently been extensively investigated due to its promising prospects. In the brain tumor microenvironments, some specific nutrient transporters and signal receptors are overexpressed in the blood epithelium or tumor cells to support the rapid growth of tumor. This article reviewed the research progress of brain-targeting biomimetic delivery strategies mediated by nutrient transports and signal receptors related pathways in recent years and their applications in brain cancer therapy.
作者
赵鹏飞
施明杰
黄永焯
ZHAO Pengfei;SHI Mingjie;HUANG Yongzhuo(State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China;College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China)
出处
《药学进展》
CAS
2018年第11期804-815,共12页
Progress in Pharmaceutical Sciences
基金
国家自然科学基金(No.81402883
No.81422048
No.81673382
No.81521005)
中国科学院先导项目(No.XDA12050307)
中国科学院科研装置研究项目(No.YZ201437)
复旦大学-中科院上海药物所融合基金(No.FU-SIMM20174009)
关键词
血脑屏障
脑靶向
脑肿瘤
仿生递药
纳米药物递送系统
blood-brain barrier
brain targeting
brain tumor
biomimetic delivery
nano-drug delivery system
