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乙型病毒性肝炎患者血清甲胎蛋白水平检测的价值评价

Evaluation of the value of serum alpha-fetoprotein level detection in patients with viral hepatitis B
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摘要 目的分析乙型病毒性肝炎患者血清甲胎蛋白(AFP)水平检测的价值。方法 120例乙型病毒性肝炎患者,抽取空腹静脉血,分离血清,离心处理后,均检测患者谷氨酰转肽酶(GGT)、碱性磷酸酶(ALP)、AFP、谷草转氨酶(AST)、谷丙转氨酶(ALT)、血清总胆红素(TBIL)水平,比较AFP阴性、阳性患者GGT、ALP、AST、ALT、TBIL水平。结果经检测, 120例患者中AFP阳性57例,阴性63例。AFP阳性患者GGT、ALP、AST、ALT、TBIL水平分别为(208.76±50.14)U/L、(212.62±32.18)U/L、(356.26±30.17)U/L、(258.26±32.62)U/L、(100.88±32.05)μmol/L,显著高于AFP阴性患者的(30.56±12.28)U/L、(65.06±8.11)U/L、(58.05±6.44)U/L、(45.33±8.59)U/L、(15.17±6.25)μmol/L,差异均具有统计学意义(P<0.05)。结论乙型病毒性肝炎患者检测AFP,可作为评估急性肝损伤患者病情的重要指标,为早期肝癌疾病的诊断提供一定的科学依据,临床价值较高,值得信赖。 Objective To analyze the value of serum alpha-fetoprotein (AFP) level detection in patients with viral hepatitis B. Methods Fasting venous blood was taken from 120 patients with viral hepatitis B and serum was separated. After centrifugation, the levels of glutamyltranspeptidase (GGT), alkaline phosphatase (ALP), AFP, aspartate aminotransferase (AST), alanine transaminase (ALT) and total bilirubin (TBIL) in serum were detected. The levels of GGT, ALP, AST, ALT and TBIL in AFP negative and positive patients were compared. Results In the 120 patients, AFP was positive in 57 cases and negative in 63 cases. Positive AFP patients had GGT, ALP, AST, ALT and TBIL levels respectively as (208.76±50.14) U/L, (212.62±32.18) U/L, (356.26±30.17) U/L, (258.26±32.62) U/L and (100.88±32.05) μmol/L, which were all significantly higher than (30.56±12.28) U/L, (65.06±8.11) U/L, (58.05±6.44)U/L, (45.33±8.59) U/L and (15.17±6.25) μmol/L in negative AFP patients, and their difference was statistically significant (P<0.05). Conclusion Detection of AFP in patients with viral hepatitis B can be used as an important index to evaluate the condition of acute liver injury and it can provide a scientific basis for the diagnosis of early hepatocellular carcinoma. It has high clinical value and is worthy of trust.
作者 许增佳 杨建辉 黄丽娟 XU Zeng-jia;YANG Jian-hui;HUANG Li-juan(Department of Infection, Guangdong Heyuan People's Hospital,Heyuan 517000, China)
出处 《中国实用医药》 2018年第35期25-26,共2页 China Practical Medicine
关键词 乙型病毒性肝炎 血清甲胎蛋白 诊断 Viral hepatitis B Serum alpha-fetoprotein Diagnosis
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