摘要
目的:探讨生血补髓汤对创伤性胫骨骨缺损骨搬运术后患者临床疗效及BMP-7和bFGF水平的影响。方法:采用随机数字表法将50例创伤性胫骨骨缺损行骨搬运术后患者随机分为两组:观察组25例,术后以常规治疗和口服生血补髓汤;对照组25例,仅以常规治疗,不服用中药。分别观察并比较两组患者术前及牵拉后4,8,12周血清中BMP-7和bFGF水平及X线片骨痂直径率(CDR),并比较两组临床疗效。结果:观察组患者牵拉后4,8及12周血清中BMP-7和bFGF水平均高于对照组,骨痂直径率CDR均高于对照组;且观察组临床疗效优于对照组,以上差异均有统计学意义(P<0.05)。结论:对于创伤性胫骨骨缺损行骨搬运的术后患者,服用生血补髓汤能显著提高BMP-7和bFGF水平的表达,促进骨缺损区的骨痂生长,提高手术疗效,值得临床使用。
Objective : To explore the effect of Shengxue Busui decoction on the clinical efficacy and the level of osteogenicfactor BMP - 7and bFGF after bone transport of traumatic tibial bone defect.Methods : 50cases of traumatic bone defect oftibia were randomly divided into two groups byusinga random number table method : 25cases in the observation groupwere treated with Shengxue Busui decoction on the basis of routine treatment , and 25cases in the control group were trea -ted with routine treatment only.The serum BMP - 7and bFGF levels and the callus diameter ratio ( CDR ) on X -rayfilmswere observed and compared between the two groups before operation and 4 , 8and 12weeks after bone traction , and theclinical efficacy of the two groups was compared.Results: The levels of serum osteogenic factor BMP - 7and bFGF in theobservation group at 4w , 8wand 12wafter traction were all higher than those of the control group, and the callus diame -ter ratios ( CDR ) were also higher than those of the control group.The clinical efficacy of the observation group was alsobetter than that of the control group , and the above differences were statistically significant ( P <0.05 ) .Conclusion : Forpatients with traumatic tibial bone defect undergoing bone transport , Shengxue Busui decoction can significantly improvethe expression of osteogenic factor BMP - 7and bFGF , promote the growth of callus in the bone defect area.It can pro -mote operative effect and is worthy of clinical application.Keywords :
作者
邹泽良
缪杰佳
吴峰
赵崇智
ZOU Zeliang;MIAO Jiejia;WU Feng;ZHAO Chongzhi(Department of Orthopedics ,Foshan hospital of Traditional Chinese Medicine ,Foshan 528000,Guangdong China;Department of orthopedics ,the Second People's Hospital of Foshan City ,Foshan 528000,Guangdong China)
出处
《中国中医骨伤科杂志》
CAS
2018年第12期30-34,共5页
Chinese Journal of Traditional Medical Traumatology & Orthopedics
基金
广东省卫生医学科研课题(B2018221)
关键词
生血补髓汤
胫骨骨缺损
骨搬运技术
成骨因子
临床观察
Shengxue Busui decoction
tibia defect
bone transport
osteogenic factor
clinical observation
