摘要
过氧化物酶体增殖物激活受体γ辅助活化因子1(PGC-1)为核转录辅助激活因子,其家族包含PGC-1α、PGC-1β和PRC3个成员。该激活因子对多种核受体的活性起着关键性的调节作用。其中PGC-1α为最先开始研究且研究最多的信号通路,是线粒体相关基因的转录辅激活因子,参与线粒体生物合成及功能的调节,且在中枢神经系统抗过氧化损伤、调节机体适应性产热、生物能量代谢以及代谢性疾病的发生和发展等方面扮演着极其重要的作用。因此PGC-1α有望成为糖尿病、中枢神经系统退行性疾病、肿瘤和心血管等代谢性疾病治疗的新靶点。以下从PGC-1α的结构、在不同细胞线粒体中的作用机制、线粒体生物合成、对线粒体功能的保护作用及与线粒体损伤疾病中的关系等方面综述PGC-1α与线粒体能量代谢的最新进展。
Over-expression of peroxisome proliferator-activated receptor γ coactivator-1 (PGC-1) is a transcriptional coactivator whose family contains three members:PGC-1α,PGC-1β and PRC,all of which play a key regulatory role in various nuclear receptor activation. PGC-1α pathway is the first and most widely researched. It is a transcriptional coactivator of mitochondrial related genes,involved in mitochondrial biogenesis and function adjustment,and resists oxidative damage in the central nervous system,regulating the body's adaptive heat production and bioenergy metabolism. What's more,PGC-1α plays an extremely important role in metabolic diseases. Therefore,PGC-1α is expected to become a new target for the treatment of diabetes,central nervous system degenerative diseases,tumors and cardiovascular diseases. The recent advances in PGC-1α and mitochondrial energy metabolism are reviewed in terms of the structure of PGC-1α,the mechanism of action in different cell mitochondria, mitochondrial biosynthesis,protection of mitochondrial function and relationship with mitochondrial damage.
作者
王博
李同兴
刘振中
WANG Bo;LI Tong-xing;LIU Zhen-zhong(Department of Preventive Medicine ,North Sichuan Medical College ,Nanchong Sichuan,637007,China)
出处
《职业与健康》
CAS
2018年第24期3445-3448,3452,共5页
Occupation and Health
基金
四川省教育厅重点项目(17ZA0177)
四川省教育厅一般项目(14ZB0190)
川北医学院博士科研启动基金(CBY17-QD06)
