摘要
To the Editor:Diabetic nephropathy (DN)is the leading cause of chronic renal diseases and accounts for almost 50% of all end-stage renal diseases worldwide.The prevalence of DN increased significantly after 2010in China.[1,2] DN is clinically characterized by proteinuria and morphological and ultrastructural changes in the kidney.The pathogenesis of DN is multifactorial and extremely complex,including hyperglycemia,transforming growth factor (TGF)-β1,angiotensin Ⅱ,DNA methylation,chromatin histone modification,microRNAs,and long noncoding RNAs.
