摘要
目的:客观评价温阳活血解毒方对急性心肌梗死(Acutemyocardialinfarction,AMI)患者的临床疗效及其对Th/Tregs水平的影响。方法:纳入合格受试对象89例,随机分为治疗组44例和对照组45例,两组患者均予西医常规治疗和/或再灌注治疗。治疗组在常规治疗基础上加服温阳解毒活血方,疗程14d,观察两组治疗前后西雅图心绞痛评分及中医症状评分,外周血IL-17、IL-35等指标变化,并与健康对照组比较。结果:治疗后两组西雅图心绞痛量表评分较治疗前均有所改善,尤其在躯体活动受限程度(PL)、治疗满意程度(TS)、疾病认知程度(DS)、心绞痛稳定状态(AS)方面改善明显(P<0.05或P<0.01)。其中治疗组在TS及DS、AS方面较对照组有统计学意义(P<0.05);治疗后中医症状评分组间比较有统计学意义(P<0.05),治疗组的症状改善程度及中医疗效评价优于对照组(P<0.05)。各组治疗前血中IL-17、IL-35、cTnI及EF值比较,治疗组、对照组与健康对照组比较,差异有显著统计学意义(P<0.05),但治疗组与对照组组间比较无统计学意义(P>0.05);治疗后,治疗组IL-35及EF水平均较治疗前提高,两组cTnI及BNP均较前下降,但IL-17改善不明显。治疗组治疗后IL-35及BNP改善程度较对照组有统计学意义(P<0.05)。两组均未发现与药物有关的不良反应。结论:温阳解毒活血方能改善AMI患者临床症状及心绞痛发作情况,其机理可能与干预Th/Tregs进而调节免疫-炎症有关。
Objective:To evaluate the clinical efficacy of Wenyang Huoxue Jiedu Decoction on AMI patients and its influence on the level of Th/Tregs. Methods:A total of 89 eligible subjects were randomly divided into treatment group(n = 44)and control group(n = 45). The two groups were treated with routine Western medicine and/or reperfusion therapy. The treatment group was treated with Wenyang Huoxue Jiedu Decoction on the basis of conventional treatment,the course of treatment was 14 days. The scores of angina pectoris,TCM symptom scores,peripheral blood IL-17 and IL-35 were observed before and after treatment in the two groups,as compared with the healthy control group. Results:The scores of Seattle angina and TCM symptom in the two groups were improved after treatment,especially in PL,TS,DS and AS(P <0.05 or P <0.01). There was statistically significant in TS、DS and AS between the two groups(P <0.05);the improvement of symptoms and curative effect of TCM in the treatment group were better than the control group(P <0.05). As far as the serum IL-17,IL-35,cTnI and EF value comparison were concerned,there was statistically significant when the two groups were compared with healthy control group(P <0.05),but the difference between treatment group and control group was not statistically significant(P >0.05),the levels of IL-35 and EF in treatment group were increased,cTnI and BNP in the two groups were descended,but IL-17 was not significantly improved after treatment. The improvement degree of IL-35 and BNP after treatment in the treatment group was more statistically significant than that of the control group(P <0.05). No adverse reactions related to drugs were found in the two groups. Conclusion:Wenyang Huoxue Jiedu Decoction could be used to improve the clinical symptoms and degree of angina pectoris in AMI patients, and its mechanism may be related to the intervention of Th/Tregs and the regulation of immune inflammation.
作者
刘静
余锋
信梦雪
洪永敦
刘南
赵静
LIU Jing;YU Feng;XIN Mengxue;HONG Yongdun;LIU Nan;ZHAO Jing(First Clinical Medical College,Guangzhou University of Chinese Medicine,Guangzhou 510405,Guangdong,China;The First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510405,Guangdong,China)
出处
《辽宁中医药大学学报》
CAS
2018年第12期180-183,共4页
Journal of Liaoning University of Traditional Chinese Medicine
基金
广东省中医药局建设中医药强省科研项目(20161126)
