摘要
随着抗生素的不合理使用,耐碳青霉烯类肠杆菌科细菌已成为公众健康的一大威胁,因其预后差,传播广泛而引起了全世界范围的关注和研究,且已经成为导致患者死亡的重要因素之一。我国的耐药菌感染率也在不断升高,以产碳青霉烯酶的耐碳青霉烯类肠杆菌科细菌(CRE)为主。在评估CRE感染的研究中,人们发现传播过程和预防感染同样重要。该文将从CRE的耐药机制,分子流行病学和危险因素等方面的研究进展进行阐述。
With the inappropriate use of antibiotics,carbapenem-resistant Enterobacteriaceae bacteria (CRE) has become a serious public health threat.Due to its worldwide prevalence and poor prognosis,infection by CRE is one of the important causes of death,which has attracted worldwide attention and research.In our country,the infection rate of drug-resistant bacteria is also increasing,mainly based on CRE producing carbapenemase.In the research of assessing CRE infection,people found that the process of transmission is as important as the prevention strategies.In this review, we will expound the research progress of the resistance mechanism of CRE,molecular epidemiology and risk factors.
作者
陶慧婷
杨旭
Tao Huiting;Yang Xu(Clinical laboratory Second Affiliated Hospital of Kunming Medical University,Kunming 650101,China)
出处
《中国临床保健杂志》
CAS
2018年第6期849-853,共5页
Chinese Journal of Clinical Healthcare
关键词
抗药性
细菌
处方不当
肠杆菌科
分子流行病学
危险因素
Drug resistance,bacterial
Inappropriate prescribing
Enterobacteriaceae
Molecular epidemiology
Risk factors
