摘要
Alzheimer's disease (AD),also known as Alzheimer's,is a chronic neurodegenerative disorder with hallmark amyloid plaques in brain tissue.The diseases commences slowly and worsens over time (Sjogren et al.1952).Although it has been investigated for over six decades,the cause of AD is still not completely understood.It was initially thought to be caused by genetic heritability (autosomal mutation leading to aggregation of β-amyloid and misfolded tau proteins)or head injury.However,hundreds of drug trials targeting the accumulation of sticky amyloid plaques and misfolded tau proteins in the brain have failed to yield any results.
基金
supported by the National Key Research and Development Program of China(2016YFC1200400)
Qiliang Cai is a scholar of New Century Excellent Talents in University of China
