摘要
心肌梗死严重威胁人类健康,给人类造成了沉重的社会负担.长链非编码RNA(long noncoding RNA,lncRNA)主要通过表观遗传调控、转录和转录后调控、miRNA调节等方式,参与心肌细胞凋亡和心肌纤维化过程,与心肌梗死发生发展有密切关系,具有作为疾病诊断和治疗靶标的潜能.我们通过高通量转录分析策略筛选在心肌梗死组织与正常心肌组织中差异表达的lncRNA,并通过对lncRNA的生物信息学分析、生物学定位以及功能的初步探索研究lncRNA与心肌梗死发生发展的关系,以确定新的可作为心肌梗死治疗靶点的lncRNA.我们的研究为利用lncRNA治疗心肌梗死提供了线索.
Myocardial infarction posed a great threat to human health,and brought a heavy burden on society.Long noncoding RNA(lncRNA)is mainly involved in cardiomyocyte apoptosis and myocardial fibrosis through epigenetic regulation,transcription and posttranscriptional regulation,miRNA regulation,and is closely related to the development of myocardial infarction.They can act as a role of diagnostic and therapeutic target for myocardial infarction.We used high-throughput transcription analysis to filtrate lncRNA that were differentially expressed in myocardial infarcts and normal myocardium.The relationship between lncRNA and development of myocardial infarction was studied by bioinformatics analysis,biological localization,and preliminary exploration of functions of lncRNA.To identify new lncRNA that can serve as therapeutic target for myocardial infarction.Our study provided clues for using lncRNA to treat myocardial infarction.
作者
郝凯丽
路兴爱
武宏春
雷伟
赵振奥
胡士军
HAO Kaili;LU Xing'ai;WU Hongchun;LEI Wei;ZHAO Zhen'ao;HU Shijun(Institute for Cardiovascular Science,Soochow University,Suzhou Jiangsu 215000,China;Department of Cardiovascular Surgery,First Affiliated Hospital of Soochow University,Suzhou Jiangsu 215006,China)
出处
《复旦学报（自然科学版）》
CAS
CSCD
北大核心
2018年第6期740-748,共9页
Journal of Fudan University：Natural Science
基金
国家重点研发计划(2017YFA0103700)
国家自然科学基金(91739106
81770257
81500277)
江苏省自然科学基金(BK20170002
BK20150345
17KJA310006)
国家临床重点专科心血管外科
江苏省医学重点学科(实验室)
江苏省临床医学研究中心的平台资助
