摘要
自身抗体是自身免疫性疾病辅助诊断、治疗监测和预后判断的重要标志物。近年来,部分实验室开始将自身抗体的临床应用扩展到体检人群自身免疫性疾病筛查甚至是疾病预测。本文将强调自身抗体检测正确的临床预期用途,讨论自身抗体检测用于体检人群自身免疫性疾病筛查和自身免疫性疾病预测存在的问题,探讨自身抗体检测临床有效应用的重要性。自身抗体检测正确的临床预期用途,是自身抗体实验室检测质量保证中分析前的第一步,是保证自身抗体检测临床应用有效性的前提。错误的临床预期用途,将使后续实验室质量保证各环节均变成"南辕北辙"的工作。
Autoantibodies are useful in diagnosis, monitoring treatment and prognosis for patients with autoimmune disease. Recently, some laboratories expanded the use of autoantibodies to the screening of autoimmune diseases for all population, as well as prediction of onsets of diseases. We will emphasize on the correct use of autoantibodies and discuss the problems to screen autoimmune diseases for all population and predict autoimmune diseases. The correct intended use for a test is the first step of quality assurance and the premise to ensure the clinical validity. Otherwise, the other actions for quality control will be in a way that defeats one′s purpose, that is " go south by driving the chariot north".
作者
张瑞
李金明
Zhang Rui;Li Jinming(National Center for Clinical Laboratories, Beijing Hospital, National Center of Gerontology, Beijing Engineering Research Center of Laboratory Medicine, Beijing 100730, China)
出处
《中华检验医学杂志》
CAS
CSCD
北大核心
2018年第12期901-904,共4页
Chinese Journal of Laboratory Medicine
关键词
自身抗体
预期用途
普查
Autoantibodies
Intended use
Mass screening Autoantibodies
Mass screening
