摘要
目的 分析狼疮性肾炎患者肾功能恶化的危险因素. 方法 回顾性分析2013年6月至2015年6月遵义医学院第三和第一附属医院收治的狼疮性肾炎患者的临床资料,其中肾功能快速恶化的狼疮性肾炎患者62例患者设为观察组,肾功能正常的狼疮性肾炎患者200例,随机选取其中62例设为对照组.采用单因素分析筛选影响狼疮性肾炎患者肾功能快速恶化的危险因素,并进一步通过多因素Logistic回归分析确定影响狼疮性肾炎患者肾功能快速恶化的独立危险因素. 结果单因素分析结果显示,感染、狼疮活动、贫血、低蛋白血症和高三酰甘油血症是影响狼疮性肾炎患者肾功能快速恶化的危险因素(均 P<0.05) ;多因素Logistic回归分析结果显示感染、狼疮活动和低蛋白血症是影响狼疮性肾炎患者肾功能快速恶化的独立危险因素(OR=3.109 、3.669 、2.691 ,P=0.003 、0.004 、0.033) . 结论 感染、狼疮活动和低蛋白血症是影响狼疮性肾炎患者肾功能快速恶化的独立危险因素,及早对这些危险因素进行纠正和干预有利于改善患者的预后,提高生活质量.
Objective To analyze the risk factors for renal function deterioration in patients with lupus nephritis.Methods Clinical data of patients with lupus nephritis admitted to the Third and the First Affiliated Hospital of Zunyi Medical College from June 2013to June 2015were reviewed and retrospectively analyzed.Of them,62lupus nephritis patients with the rapid deterioration of renal function were selected as an observation group,and 62patients were selected randomly from 200lupus nephritis patients with normal renal function and were considered as a control group.Risk factors for the rapid deterioration of renal function in patients with lupus nephritis were analyzed by univariate analysis.Furthermore,multivariate Logistic regression analysis was used to identify the independent risk factors for the rapid deterioration of renal function in patients with lupus nephritis.Results Univariate analysis revealed that infection,lupus activity,anemia,hypoproteinemia and hypertriglyceridemia were risk factors for the rapid deterioration of renal function in patients with lupus nephritis (P<0.05).Multivariate logistic regression analysis showed that infection,lupus activity and hypoproteinemia were the independent risk factors for the rapid deterioration of renal function in patients with lupus nephritis(OR =3.109,3.669and 2.691,P =0.003,0.004and 0.033, respectively).Conclusions Infection,lupus activity and hypoproteinemia are the independent risk factors for the rapid deterioration of renal function in patients with lupus nephritis.Early prevention and intervention can improve clinical outcome and quality of life in lupus nephritis patients.
作者
罗亚丹
袁立英
赵瑾
裘志成
Luo Yadan;Yuan Liying;Zhao Jin;Qiu Zhicheng(Department of Nephropathy and Rheumatism,the Third Affiliated Hospital of Zunyi Medical College,Zunyi 563003,China;Department of Rheumatism and Nephropathy ,the First Affiliated Hospital of Zunyi Medical College,Zunyi 563003,China)
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2018年第12期1387-1389,共3页
Chinese Journal of Geriatrics
关键词
狼疮肾炎
肾功能不全
危险因素
Lupus nephritis
Renal insufficiency
Risk factors
