摘要
目的通过建立实验性大鼠压力性尿失禁模型,观察采用Bulkamid微创填充技术治疗大鼠模型的疗效。方法 80只3～4个月的雌性孕鼠,产后立即用气囊扩张阴道4 h模拟第二产程延长时胎头对盆底及下尿道的压力,待手术完全恢复后,用喷嚏负荷试验观察有无压力性尿失禁的发生。并通过尿动力学检查记录大鼠最大膀胱容积、漏尿点压、喷嚏负荷实验阳性率指标。将压力性尿失禁模型大鼠随机分为实验组(Bulkamid技术治疗组)和对照组(空白对照组),各40只。实验组使用注射器将水化填充剂注射到大鼠模型后尿道或膀胱内口黏膜及肌层中。对照组不给予任何干预。通过喷嚏负荷实验、尿动力学检查,比较两组大鼠最大膀胱容积、漏尿点压、喷嚏负荷实验阳性率指标。结果获得科学有效的压力性尿失禁大鼠模型制备技术,成功制备了压力性尿失禁大鼠模型。实验组大鼠最大膀胱容积、漏尿点压及喷嚏负荷实验阳性率分别为(1.21±0.25)ml、(24.20±3.35)mm Hg(1 mm Hg=0.133 kPa)、12.5%(5/40),均分别优于对照组的(0.83±0.13)ml、(17.90±3.40)mm Hg、42.5%(17/40)。结论 Bulkamid微创填充治疗压力性尿失禁模型具有较好的疗效,为今后女性压力性尿失禁的有效治疗提供新思路,为Bulkamid技术的推广应用提供理论和技术基础。今后,可以为大量的患者提供安全、科学、有效的治疗手段,缩短住院和康复时间,最大限度的恢复患者的健康,具有较大的社会经济意义。
Objective To observe the therapeutic effect of Bulkamid minimally invasive filling technique on stress urinary incontinence in rats by establishing an experimental model of stress urinary incontinence. Methods A total of 80 pregnant female mice of 3~4 months were given balloon dilatation of vagina for 4 hours immediately after delivery to simulate the pressure of fetal head on pelvic floor and lower urethra during prolonged second stage of labor. After complete recovery of operation, the occurrence of stress urinary incontinence was observed by sneeze load test. The maximal bladder volume, leak point pressure and positive rate of sneeze load test were recorded by urodynamic examination. The stress urinary incontinence model rats were randomly divided into experimental group(Bulkamid treatment group) and control group(blank control group), with 40 rats in each group. The experimental group received injection of hydration filler into the posterior urethra or intravesical orifice mucosa and muscular layer of the rat model with syringe, and the control group received no intervention. The maximal bladder volume, leakage point pressure and positive rate of sneezing load test were compared between the two groups by sneezing load test and urodynamic test. Results A rat model of stress urinary incontinence was successfully prepared by obtaining a scientific and effective rat model of stress urinary incontinence. The experimental group had maximal bladder volume, leakage point pressure and positive rate of sneezing load test respectively as(1.21±0.25) ml,(24.20±3.35) mm Hg(1 mm Hg=0.133 kPa) and 12.5%(5/40), which were all better than(0.83±0.13) ml,(17.90±3.40) mm Hg and 42.5%(17/40) in the control group. Conclusion Bulkamid minimally invasive filling has a good effect in the treatment of stress urinary incontinence model. It provides a new idea for the effective treatment of female stress urinary incontinence in the future, and provides a theoretical and technical basis for the popularization and application of Bulkam
作者
刘立立
曲学玲
黄鑫
柴丽娅
金振杰
LIU Li-li;QU Xue-ling;HUANG Xin(Dalian Maternal and Child Health Hospital,Dalian 116033,China)
出处
《中国实用医药》
2018年第34期197-198,共2页
China Practical Medicine
基金
大连市卫计委课题(项目编号:2014-67)
关键词
压力性尿失禁
Bulkamid微创填充技术
疗效
Stress urinary incontinence
Bulkamid minimally invasive filling technique
Efficacy
