摘要
抑郁症是一种比较常见的精神障碍疾病,预计到2020年,抑郁症的全球发病率约为20%,将给社会带来巨大的经济负担。抑郁症存在致病因素复杂、诊断手段不够客观、治愈率低等问题。目前使用的抗抑郁药物常伴有不同程度的不良反应,且患者依从性差,因此天然药物中具有抗抑郁作用的单一成分或复方中药在抑郁症的治疗中逐渐被发现。小檗碱(C_(20)H_(18)NO_4)是我国传统中药黄连的主要成分之一。近年来越来越多的研究证据表明,小檗碱对不同抑郁样动物模型表现出良好的抗抑郁作用,其作用机制被认为与调节大脑内单胺类成分及代谢、抗炎、抗氧化作用等方面有关。本文对小檗碱抗抑郁作用及作用机制进行了综合阐述,为进一步深入探索和系统研究小檗碱的抗抑郁作用提供依据。
Depression is a common mental disorder.It is estimated that by 2020,the global incidence of depression will be about 20%,which will bring huge economic burden to society.The pathogenesis of depression is complicated,the diagnostic method is not objective,and the cure rate is low.Antidepressants are often associated with adverse reactions during treatment,and patient compliance is poor.Therefore,a single component with antidepressant effects in natural medicines or a compound Chinese medicine gradually shows an advantage in the treatment of depression.Berberine (C20H18NO4)is one of the main components of traditional Chinese me-dicine Coptis.In recent years,a large amount of evidence indicates that berberine has a good antidepressant effect on different animal models of depression,and its mechanism may be related to the regulation of monoamines and metabolism,anti-inflammatory and anti-oxidation in the brain.This article describes the antidepressant effect and mechanism of berberine,and provides a basis for further exploration and research on the antidepressant effect of berberine.
作者
孙亚南
刘敏
王琪
于春月
魏太明
SUN Ya-nan;LIU Min;WANG Qi;YU Chun-yue;WEI Tai-ming(Daqing Campus of Harbin Medical University,Daqing 163319,China)
出处
《药学学报》
CAS
CSCD
北大核心
2018年第12期2006-2011,共6页
Acta Pharmaceutica Sinica
基金
哈尔滨医科大学大庆校区"校内科研基金"
关键词
小檗碱
抑郁症
单胺类神经递质
炎性因子
氧化应激
berberine
depression
monoamine neurotransmitter
inflammatory factor
oxidative stress
