摘要
目的探讨肠源性内毒素血症对慢性乙型肝炎患者细胞免疫功能影响。方法选取该院2016年8月‐2017年12月收治的慢性乙型肝炎患者90例作为观察组,选取同期在该院进行体检的健康者40例作为对照组,检测并对比两组血浆内毒素水平(ET)、T淋巴细胞亚群(CD4^+、CD8^+)、肿瘤坏死因子-α(TNF-α)以及白细胞介素-2(IL-2)水平。结果对照组IL-2、CD4^+和CD4^+/CD8^+水平明显高于观察组,ET、TNF-α和CD8^+水平明显低于观察组,差异有统计学意义(P <0.05)。结论慢性乙型肝炎患者体内ET水平较高,细胞免疫功能低下。
[Objective]To investigate the effect of intestinal endotoxemia on cellular immune function in patients with chronic hepatitis B.[Methods]Ninety patients with chronic hepatitis B treated in our hospital from August 2016to December 2017were selected as observation group,and 40healthy cases with physical examination were selected as control group.The plasma endotoxin -(ET),T lymphocyte subsets (CD4^+,CD8^+),tumor necrosis factor-α(TNF-a),interleukin-2(IL-2)levels were compared between the two groups.[Results]The levels of IL-2,CD4^+,CD4^+/CD8^+in control group were higher than those in observation group,while the levels of ET,TNF-α,CD8+were lower than those in observation group (P <0.05).[Conclusion]Chronic hepatitis B patients have higher ET levels and lower cellular immune function.It is necessary to decrease the ET levels of patients during treatment.
作者
庄洁伟
郭辉
郭文丽
汪小娟
ZHUANG Jiewei;GUO Hui;GUO Wenli;WANG Xiaojuan(Department of Laboratory,Bao'an People's Hospital,Shenzhen,Guangdong 518100,China)
出处
《中国医学工程》
2018年第11期10-12,共3页
China Medical Engineering
