摘要
肺炎链球菌是导致发病率和致死率最主要的病原之一,特别是在儿童和老年人中。目前市售的肺炎链球菌疫苗由于其血清学的限制,具有很大的局限性,因此迫切需要研制更为经济且有广谱保护性的肺炎链球菌蛋白疫苗。肺炎链球菌的毒力因子及表面表达的抗原作为其潜在的蛋白疫苗成分,已经取得了很大的进展。本文总结了已经进入临床试验的肺炎链球菌蛋白疫苗的成分、结构特征、作用机制以及现阶段动物试验和临床研究的进展,以利于我们更好地了解肺炎链球菌蛋白疫苗的研发动态,为开发功能性抗体评价的新方法提供参考。
Streptococcus pneumoniae remains a leading cause of morbidity and mortality,especially among younger children and the elders.Streptococcus pneumococcus vaccines on the market have major disad- vantages because of the limitation of serotypes.Therefore,it is an urgent need to develop an economic and broadly protective vaccines based on the bacterial proteins.The virulence factors and antigens expressed on the surface as potential candidates make a big progress.This review summarizes the components of protein- based pneumococcal vaccines in clinical trials,and the characteristics of the proteins,the protection in the infected animals and clinical trials.It will help readers to understand current status of protein-based pneumo- coccal vaccines.
作者
黄洋
叶强
Huang Yang;Ye Qiang(Division of Respiratory Bacterial Vaccine,National Institutes for Food and Drugs Control (NIFDC),Beijing102629,China)
出处
《中华微生物学和免疫学杂志》
CAS
CSCD
北大核心
2018年第11期872-876,共5页
Chinese Journal of Microbiology and Immunology
关键词
肺炎链球菌
疫苗
蛋白质
Streptococcus pneumoniae
Vaccine
Protein
