摘要
目的了解氯沙坦的抗动脉粥样硬化 (atherosclerosis,AS)作用及其机制。 方法通过高脂饮食及内皮损伤术建立兔AS模型 ,一组用氯沙坦 (2 5mg·kg-1·d-1) ,另一组不用 ,并设正常对照组 ,喂养 4个月 ,观察血管内膜、血管壁血管紧张素Ⅱ (AII)含量及内膜巨噬细胞的变化。 结果氯沙坦治疗组兔主动脉内膜面积及内膜厚度等参数均小于未治疗组 ,其AII的含量亦明显低于未治疗组 ,内膜巨噬细胞阳性面积的表达率亦明显减少。 结论氯沙坦具有抗AS作用 。
Objective To investigate the role of angiotensin Ⅱ receptor antagonist losartan in the rabbit model of atherosclerosis. Methods Atherosclerosis was induced in the aortic arteries of rabbits by endothelial damage after feeding with an atherogenic diet for 4 months. These atherosclerotic animals were randomized to receive losartan (25mg·kg -1 ·d -1 ) or no medication, and killed in 4 months. Eight normal controls were also studied. Results Losartan induced a significant reduction in the intimal areas and angiotensin Ⅱ was significantly diminished in the aorta of the rabbits. Conclusion Block of angiotensin Ⅱ function in the vascular tissues by losartan may play an important role in preventing the development of atherosclerotic lesions.
出处
《上海第二医科大学学报》
CSCD
2002年第2期128-130,共3页
Acta Universitatis Medicinalis Secondae Shanghai
基金
卫生部自然科学基金项目 (96-2 -2 79)
