摘要
应用UMR 10 6成骨细胞株 ,观察通补强骨方中的四味主要药物 淫羊藿、女贞子、黄芪、大黄对成骨细胞株增殖情况的影响。结果发现 :四种药物在适当浓度均能促进成骨细胞增殖。其中黄芪在低浓度 (5mg L)即显示促增殖作用 ,其作用强度与剂量无明显联系 ;淫羊藿、女贞子高浓度组 (5 0 0mg L)较低浓度组 (5mg L)促增殖作用有上升趋势 ;大黄中浓度 (10 0mg L)有促增殖作用 ,高浓度 (10 0 0mg L)
It has been shown that Tong Bu Qiang Gu Fang (TBQGF) has a good effect on the treatment of osteoporosis. Using the cell strain UMR 106, we observed the effects of several Chinese herbs, which were most important in the composition of TBQGF, on the proliferation of osteoblast like cells in vitro. And we found that all of the Chinese herbs at appropriate concentrations could significantly promote the proliferation of osteoblasts. The high concentrations (500mg/L) of the Epimedii Hb and Ligustri Lucidi Fr had stronger effects on the proliferation of osteoblast like cells than the low concentration (5mg/L). Astragali Membranace Rx showed a good effect at low concentration (5mg/L), but no dose dependence relationship. Radix et Rhizoma of low concentration had no effect at all, the medium concentration (100mg/L) of it showed a significant promoting proliferation effect, while the high concentration (1000mg/L) inhibited the proliferation of the cells. The results suggested that the herbs could promote the proliferation of osteoblast like cells.
出处
《中国实验方剂学杂志》
CAS
2002年第2期18-21,共4页
Chinese Journal of Experimental Traditional Medical Formulae
