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美洛培南对临床分离菌耐药性测定 被引量:3

Determination of the Resistance of Clinically Isolated Bacteria to Meropenem
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摘要 目的 :探讨美洛培南对临床分离菌的耐药性。方法 :选取150株临床分离菌应用K -B法测定美洛培南等抗生素的耐药性 ,同时比较了美洛培南及亚胺培南对大肠埃希氏菌的耐药谱。结果 :美洛培南对临床分离菌敏感率为100 % ,美洛培南与亚胺培南对大肠埃希氏菌无交叉耐药。结论 :美洛培南对临床分离菌有高度敏感性 。 OBJECTIVE:To determine the resistance of clinically isolated bacteria to meropenem METHODS:The resistance of 150 clinically isolated strains to meropenem and several other antibiotics was detected by K-B method and the drug resistant spectra to E coli were compared between meropenem and imipenem RESULTS:The sensitivity of 130 clinical isolates to meropenem was 100% No cross resistant strains of E coli was found to meropenem and imipenem CONCLUSION:Meropenem is highly sensitive to the clinical isolates,and its antibacterial spectrum is similar to that of imipenem
出处 《中国药房》 CAS CSCD 2002年第2期108-109,共2页 China Pharmacy
关键词 细菌 美洛培南 耐药性 测定 bacterium meropenem drug resistance
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  • 1[1]Norrby SR, Faulkner KL, Newell PA.Differentiatiny meropenem and imipenem/cilastatin[J].Infections Dis- eas in Clinical Practice, 1997, 6( 5):291. 被引量:1
  • 2[2]Fuka Sawa M, Sumita Y, Harabe ET, et al Statbility of meropenem and effect of 1- β - methyl substitution on its stability in the presence of renal dehydropeptidasel [J].Antimicrob Agents Chemother, 1992, 36:1 577. 被引量:1
  • 3[3]Norrby SR, Gildon KM Safety profile of meropenem:a review of nearly 5 000 patients treated with meropene- m[J].Scand J Infect Dis, 1999, 33:3. 被引量:1
  • 4[4]Pfaller MA, Jones RN A review of the in vitro of mer- openem and comparative antimicrobial agents tested ag- ainst 30 254 aerobic and anaerobic pathogens isolated world wide[J].Diagn Microbiol Infect Dis, 1997, 28( 4):157. 被引量:1

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