摘要
目的 :利用大鼠髓核突出动物模型 ,探索皮层躯体感觉诱发电位 (CSEP)的波幅和潜伏期变化是否与神经根性疼痛有关系。方法 :取大鼠自体尾部的髓核无压迫下放置在L4 和L5神经根上 ,制成髓核突出动物模型 ,分别在术后3d、1、2及 4周观察大鼠术侧肢体机械刺激敏感性和热刺激敏感性的变化 ,并引出大鼠后肢CSEP ,观察术侧肢体CSEP的变化。结果 :在无明显机械压迫的情况下 ,大鼠腰神经根上植入自体髓核可产生痛觉过敏 ,CSEP波幅增高。结论 :髓核自身是引起腰腿痛的重要原因 ,CSEP波幅的增高与神经根性疼痛有一定的相关性。
Objective: To determine whether the changes of cortical somatosensary evoked potentials (CSEP) are associated with radiculopathy caused by herniated nucleus pulposus in lumbar spine.Methods:The nucleus pulposus of coccygeal vertebra was applyed to the L 4 and L 5 nerve roots of the rat without compression and the mechanical withdrawal threshold and thermal withdrawal latency were observed and CSEP of hindlimbs were recorded in 3 days, 1 week,2 weeks and 4 weeks respectively after surgery in order to show the changes of CSEP in the operated limb.Results:The rat showed obvious hyperalgesia after the application of autologous nucleus pulposus on the nerve root without compression and the amplitude of CSEP increased obviously in the operated limb.Conclusions:The biologic effect of nucleus pulposus is an important factor in the pathogenesis of low lumbar and leg pain and the increasing amplitude of CSEP may be related to the pain.
出处
《中国矫形外科杂志》
CAS
CSCD
2002年第2期170-172,共3页
Orthopedic Journal of China
