期刊文献+

高甘油三酯—低高密度脂蛋白血症与冠状动脉病变 被引量:6

The Relations between Hypertriglyceridemia, Hypo-High-Density-Lipoproteinemi a and Coronary Artery Disease
下载PDF
导出
摘要 为了分析高甘油三酯血症—低高密度脂蛋白血症与冠状动脉病变的关系 ,对 5 4例稳定型心绞痛和陈旧性心肌梗死患者行冠状动脉造影术 ,同时测定吸烟年限、血糖、收缩压、胆固醇、低密度脂蛋白、甘油三酯、高密度脂蛋白等冠心病危险因素 ,将研究对象分为无主要危险因子组 (n =15 )、高甘油三酯—低高密度脂蛋白血症组 (n =11)、合并糖尿病组 (n =15 )及合并糖尿病和高甘油三酯—低高密度脂蛋白血症组 (n =13) ,比较各组冠状动脉病变程度、类型和罹患支数 ,并应用逐步回归法研究上述因素与冠状动脉狭窄度积分的关系。结果发现 ,合并糖尿病和高甘油三酯—低高密度脂蛋白血症组冠状动脉狭窄度积分较其它各组显著增高 (P <0 .0 5 ) ,B2 、C型病变较无主要危险因子组多见 (P <0 .0 5 ) ,且三支病变显著增多 ;冠状动脉狭窄度积分与血糖、甘油三酯、高密度脂蛋白等因素存在线性回归关系 (P <0 .0 5 )。提示 ,血浆甘油三酯浓度越高 ,高密度脂蛋白浓度越低 ;血糖浓度越高 ,冠状动脉狭窄度积分越高 ,冠状动脉病变程度越重。 Aim To investigate the relationship between cor onary artery disease and hypertriglyceridemia? hypo high density lipoprotei nemia. Methods 54 cases with stable angina pectoris or old myocardial infarction were divided into four groups: 15 cases in non major risk factor group, 11 cases in hypertriglyce ridemia and hypo high density lipoproteinemia group, 15 cases in diabetes mel litus g roup, and 13 cases in diabetes mellitus and hypertriglyceridemia and hypo high densit y lipoproteinemia group. Some risk factor such as smoking years, blood glucos e, systolic blood pressure, choleserol, low density lipoprotein cholesterol(LDLc ), trig lyceride, high density lipoprotein cholesterol (HDLc) were measured. The rel ationship between above factors and the degrees of coronary artery lesion with a ngiography were detected. Results The coronary arter y stenosis s core was significantly higher in diabetes mellitus and hypertriglyceridemia, and hypo high density lipoproteinemia group (10.5±3.4) than in other groups (P<0.05), the B 2?C type of coronar y artery disease in diabetes mellitus and hypertriglyceridemia and hypo high d en sity lipoproteinemia group were significantly more than in non major risk fac tor group (P<0.05), and three vessel diseases increase more in this group; the lineal regression relationship were found between blo od glucose, triglyceride, HDLc and coronary artery stenosis score with stepwise regression analysi s. Conclusions The higher the levels of blood gluc ose and triglyceride become, the lower the level of HDLc. The coronary artery s tenosis score will become higher, with the degree of coronary artery lesion be coming heavier.
出处 《中国动脉硬化杂志》 CAS CSCD 2002年第1期59-61,共3页 Chinese Journal of Arteriosclerosis
关键词 冠状动脉造影 甘油三酯 低高密度脂蛋白血症 血糖浓度 冠状动脉病变 Coronary Artery Angiography Triglyceride Lipoprotein , HDL
  • 相关文献

参考文献9

  • 1Reaven GM. Role of insulin resistance in human disease. Diabetes, 1988, 1 595-607 被引量:1
  • 2Rubins HB, Robims ST, Fye CL, et al. Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high density lipoprotein cholesterol. N Engl J Med, 1999, 341: 410-418 被引量:1
  • 3Plump AS, Scott CJ, Breslow JL, et al. Human apolipoprotein AI gene expression increases high density lipoprotein and suppresses atherosclerosis in the apolipoprotein E-deficient mouse. Proc Natl Acad USA, 1994, 91: 9 607-610 被引量:1
  • 4Mabuchi H, Koizumi J, Shimizu M, et al. Development of coronary heart disease in familial hypercholesterolemia. Circulation, 1989, 79: 2 255-262 被引量:1
  • 5Sasai K, Noji KO, Hibino T, et al. Human cholestery1 ester transfer protein measured by enzyme-linked immunosorbent assay with two monoclonal antibodies against rabbit cholestery1 ester transfer protein:plasma cholestery1 ester transfer protein and lipoproteins among Japanese hypercholesterolemic patients. Clin Chem, 1998, 44: 1 466-473 被引量:1
  • 6谷口博幸 平野铃子 他.MRA にょる大动脉(AO)プテ一クの描出と血中Fibrinogen および血中脂质浓度との关联性についての检讨[J].J Cardiol,2000,36(1):324-324. 被引量:1
  • 7Downs J, Clearfield M, Weis S, et al. Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels. JAMA, 1998, 279: 1 615-622 被引量:1
  • 8杨志明,肖传实,边云飞,梁树芬,王凤芝,王友桂.辛伐他汀对冠心病患者低密度脂蛋白氧化修饰及血小板活化状态的影响[J].中国动脉硬化杂志,1999,7(2):161-163. 被引量:6
  • 9杉下靖郎, 门间和夫, 矢崎义雄. Annual Review 2001-循环器. 中外医学社, 2001, 77-82 被引量:1

二级参考文献5

共引文献5

同被引文献60

引证文献6

二级引证文献63

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部