摘要
目的 探讨低剂量锰对小鼠精子的损害作用。方法 用低剂量锰 (2 5 ,5 ,10 ,2 0mg/kg)腹腔注射染毒昆明种小鼠 ,12周后对精子畸形率、活动度、精子总数、睾锰含量和睾丸系数进行观察。结果 精子总数、活动度、睾丸系数随染毒剂量升高而降低 ;精子畸形率、睾锰含量随染毒剂量增加而升高。结论氯化锰 2 5mg/kg对精子仍有毒性损害作用 。
Objective\ To study the effects of low concentration Mn exposure on male mice reproductive functions.Methods\ The morphology,activity,quantity of sperm,the level of Mn in testicle and the weight coefficient were investigated after a successive 12 weeks i p administration of Mn(2\^5,5,10,20 mg/kg).Results\ Results showed that the quantity,activity and the weight coefficient were significantly decreased as the dose increased.The ratio of sperm deformity and the level of Mn in testicle were significantly increased as the dose increased.Conclusions\ It suggested that low concentration of Mn might have sperm toxicity in mice.
出处
《工业卫生与职业病》
CAS
CSCD
北大核心
2002年第1期17-19,共3页
Industrial Health and Occupational Diseases
