摘要
目的 设计合成一系列香豆素西佛碱化合物并进行抗癌筛选。方法 合成了 2 1个取代的 4 ,6 或 7 位苯基亚胺次甲基香豆素 ,其结构经MS ,HNMR和元素分析确证 ,并对其进行体外抗癌筛选。结果 12个化合物 (3c ,3d ,3e ,3f,3g ,3h ,3j,3k ,3m ,3o ,3p ,3q)分别对KB ,HCT 8,Bel74 0 2细胞株有效。结论 该类化合物有一定抗癌活性 ,值得进一步研究。
AIM A series of substituted phenyliminomethylenecoumarins derivatives was designed in order to find compounds possessing anticancer activities. METHODS Title compounds (1a～b, 2a～b and 3a～q) were synthesized and screened by several anticancer models in vitro . RESULTS Twenty one new compounds (1a～b, 2a～b and 3a～q) were synthesized and screened. Structrues of the new compunds were determined by MS, HNMR and elemental analysis. Twelve compounds (3c, 3d, 3e, 3f, 3g, 3h, 3j, 3k, 3m, 3o, 3p, 3q) showed inhibitory effects on HCT 8, KB and Bel7402 cell lines in vitro . CONCLUSION Some compounds had certain anticancer activities and were worth further studying.
出处
《药学学报》
CAS
CSCD
北大核心
2002年第2期113-116,共4页
Acta Pharmaceutica Sinica
关键词
香豆素
西佛碱
抗癌活性
中药
coumarin
Schiff′s base
anticancer activity
