摘要
目的 对金石颗粒减低鼻咽癌放射反应的作用进行研究 ,为临床提供有效的治疗药物。方法 将 90例鼻咽癌首次根治性放射治疗患者随机均衡地分为治疗 1组 (金石颗粒剂加放疗 )、治疗 2组 (鼻咽清毒剂加放疗 )、对照组 (安慰剂加放疗 ) 3组 ,各 30例。结果 ①治疗 1组对鼻咽癌的缓解率为 93 33%、放疗完成率为 96 6 7%,Karnofsky评分的提高稳定率为 90 0 0 %,分别高于其他两组 (P <0 0 5、P <0 0 1) ;②治疗 1组出现的放射反应程度明显轻于其他两组 (P <0 0 5、P <0 0 1) ;其外周血象得到稳定 (P >0 0 5 ) ,且其稳定性优于其他两组 (P <0 0 5、P <0 0 1)。结论 金石颗粒剂有显著的减毒作用 ,可改善生活质量 ,配合放疗对鼻咽癌有较好的治疗作用。
Objective To study the effects of Jinshi Granule (JSG) on decreasing the toxic reaction of radiotherapy in nasopharyngeal carcinoma (NPC) patients in order to search for an effective method and medicines. Methods Altogether 90 patients with NPC treated by radical radiotherapy were divided into three groups at random. Each group consisted of 30 patients who all received radiotherapy.Patients of the 1st treatment group were treated by JSG,the 2nd treatment group by Biyan Qingdu Ji(BQJ),and the control group by placebo. Results ①In JSG group,the effective rate,the rate of completing radiotherapy,the enhancing and stabilization rate of quality of life were 93.33%,96.67%,and 90.00%,respectively,which were all higher than those in other groups(P<0.05,P<0.01).②The degree of the toxic reaction syndromes in the JSG group was lower than that in other two groups and the stabilization of peripheral hemogram was much better (P<0.05,P<0.01). Conclusion These data show that JSG has significant effects on reducing the toxic reaction of radiotherapy to NPC and combining it with radiotherapy is an effective method in treating NPC.;
出处
《中华放射医学与防护杂志》
CAS
CSCD
北大核心
2002年第1期39-42,共4页
Chinese Journal of Radiological Medicine and Protection
基金
湖南省卫生厅中医药科研基金资助项目 ( 96 0 0 1)
