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前列腺素E_1与日本血吸虫病肝纤维化关系的研究 被引量:5

STUDY ON THE RELATIONSHIP BETWEEN PROSTAGLANDIN E_1 AND HEPATIC FIBROSIS IN RATS WITH SCHISTOSOMIASIS JAPONICA
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摘要 目的 了解前列腺素 E1 (PGE1 )对日本血吸虫病肝纤维化形成的影响。方法 采用免疫组化 SABC技术 ,并用计算机彩色病理图文分析系统 ,检测分析感染日本血吸虫大鼠经 PGE1 治疗后肝内 、 型胶原及转化生长因子 β1 (TGF- β1 )的含量变化。结果  PGE1 治疗组肝内 、 型胶原及转化生长因子 β1 (TGF- β1 )的含量分别低于感染对照组 (P<0 .0 5 ) ;PGE1 治疗组及感染对照组肝内 、 型胶原的含量均与 TGF- β1 呈显著正相关 (r=0 .96 36 ,P<0 .0 5 ;r=0 .86 6 7,P<0 .0 5 ;r=0 .96 36 ,P<0 .0 5 ;r=0 .92 72 ,P<0 .0 5 )。结论  PGE1 对日本血吸虫病肝纤维化的形成有抑制作用 ,其机理可能与 PGE1 抑制 TGF- β1 的表达有关。 Objective To investigate the effect of prostaglandin E 1 (PGE 1 ) on hepatic fibrosis in schistosomiasis japonica. Methods Immunohistochemical SABC technique and computer multimedia pathologic picture analysis were used. Meanwhile, the amounts and distributions of type Ⅰ collagen, type Ⅲ collagen and transforming growth factor beta 1 (TGF β 1 ) were determined in the livers of PGE 1 treated rats with schistosomiasis japonica. Results Amounts of type Ⅰ collagen, type Ⅲ collagen and TGF β 1 in PGE 1 treated rats with schistosomiasis japonica were less than those in infected rats without treatment. A positive correlation could be demonstrated between type Ⅰ collagen and TGF β 1 by Spearman analysis and that between type Ⅲ collagen and TGF β 1 in infected rats with PGE 1 treatment and infected rats without treatment. Conclusion PGE 1 significantly suppressed hepatic fibrosis in schistosomiasis japonica whose mechanism was probably associated with suppressing of TGF β 1 expression by PGE 1 .
出处 《中国血吸虫病防治杂志》 CAS CSCD 2002年第1期8-10,F002,共4页 Chinese Journal of Schistosomiasis Control
关键词 血吸虫病 虫卵肉牙肿 转化生长因子 肝纤维化 日本血吸虫 前列腺素E1 Schistosomiasis Egg granuloma Transforming growth factor Hepatic fibrosis
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  • 1刘莉,中国寄生虫学与寄生虫病杂志,1995年,13卷,35页 被引量:1

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