摘要
目的 :探讨膀胱炎性假瘤的病理学特征。方法 :描述 4例膀胱炎性假瘤的临床病理及免疫组化特征并复习有关文献。结果 :男女各 2例患者 ,年龄分别为 36、2 7、36、8岁。肿瘤直径分别为 3、4、3及 5cm。主要临床症状为肉眼血尿或排尿困难。组织学检查 :肿瘤主要成分为梭形细胞 ,胞质嗜酸性 ,有大的卵圆形至梭形泡状核 ,有 1～ 2个明显的核仁。分裂象少见 ,无不典型核分裂。 3例免疫表型 :3例Vim呈弥漫阳性 ;α SMA(2例 )及MSA(1例 )局部少数细胞阳性 ;2例AE1/AE3多数细胞呈阳性。Des、Myo及EMA均阴性。 3例术后分别随访 40、16、14个月无复发 ,1例为近期病例。 结论 :病损为一种良性、非肿瘤性肌纤维母细胞增殖 。
Purpose To investigate the pathologic features of inflammatory pseudotumor of the urinary bladder. Methods Four cases of inflammatory pseudotumor of the urinary bladder were described with review of the literature. Results The age of the two female and two male patients was 36,27,36 and 8 years,and the tumor size was 3,4,3 and 5 cm respectively.The main presenting symptom was gross hematuria or dysuresia. Histological examination showed that the lesions consisted of spindle cells with tapering eosinophilic cytoplasm. These cells had large oval to spindle nuclei with a vesicular appearance and one or two prominent nucleoli. Mitotic figures were rare and never abnormal. The immunohistochemical stains were performed on 3 cases,and showed immunoreactivity for vimentin (3 cases,diffusely),α SMA(2 cases, few cells, focally), MSA(1 case, few cells focally), and AE1/AE3(2 cases, many cells). None of the cases were immunoreactive for desmin, myoglobin and EMA. Clinical follow up in 3 cases demonstrated no evidence of recurrence (follow up for 40, 16, and 14 months respectively). Conclusions This lesion is a benign non neoplastic myofibroblastic proliferation. An awareness of it is of importance to avoid an erroneous diagnosis of malignancy.
出处
《临床与实验病理学杂志》
CAS
CSCD
2001年第6期469-471,共3页
Chinese Journal of Clinical and Experimental Pathology
关键词
膀胱肿瘤
肉芽肿
浆细胞
假肉瘤性肌纤维母细胞增生
鉴别诊断
bladder neoplasms
granuloma,plasma cell
psedosarcomatous myofibroblastic proliferation
dignosis,differential
