摘要
目的 :探讨血浆D 二聚体与 2型糖尿病微血管病变的关系。方法 :对 5 2例符合WHO诊断标准的 2型糖尿病患者 ,按尿白蛋白排泄率分为三组 ,用酶联免疫吸附双抗体夹心法测定血浆D 二聚体水平 ,LBY N6A型黏度计测血液黏度 ,并与正常对照比较。结果 :尿白蛋白排泄率增高的患者 (包括早期糖尿病肾病及临床糖尿病肾病组 ) ,D 二聚体及血液黏稠度均显著高于单纯糖尿病组和正常对照组。D 二聚体与视网膜病变、空腹血清胰岛素、糖尿病病程正相关 ;而与血液黏度指标及纤维蛋白原无相关性。结论 :2型糖尿病并微血管病变者 ,血浆D 二聚体水平增高 ,可作为血栓形成标志物 ;D 二聚体为 2型糖尿病微血管病变的重要危险因素之一。
Objective To study the relationship between the level of plasma D dimer and microangiopathy of the type 2 diabetes mellitus. Methods The level of plasma D dimer and blood viscosity were measured in 52 cases with type 2 diabetes mellitus, and these patients were divided into three groups according to the level of urinary albumin excretion (UAE) together with 15 age matched healthy volunteers as the control (NC group). Results In the cases with higher urinary albumin excretion rate, including 28 cases with trace albuminuria (EDN group) and 10 cases with clinical albuminuria (CDN group), plasma D dimer and blood viscosity were increases than 14 cases without albuminuria (SDM group) and NC group. D dimer was positively correlated with diabetic retinopathe, Serum insulin and diabetic durations, but not correlated with blood viscosity and fibrinogen. Conclusion The type 2 diabetes mellitus complicated with microangiopathy had a higher level of plasma D dimer. As a marker of thrombus formation, D dimer may play an important role in the pathogenesis of diabetic microangiopathy.
出处
《湖南医科大学学报》
CSCD
北大核心
2001年第5期434-436,共3页
Bulletin of Hunan Medical University
